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Department of Applied Mathematics and Statistics newsletter, September 25, 2023 [PDF]

, 2023
Newsletter of the Department of Applied Mathematics and Statistics at Colorado School of ...

core  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Fractional Gaussian Noise: Projections, Prediction, Norms

Fractal and Fractional
We examine the one-sided and two-sided (bilateral) projections of an element of fractional Gaussian noise onto its neighboring elements. We establish several analytical results and conduct a numerical study to analyze the behavior of the coefficients of ...
Iryna Bodnarchuk, Yuliya Mishura, Kostiantyn Ralchenko   +2 more
doaj   +1 more source

Estimates for distribution of suprema of solutions to higher-order partial differential equations with random initial conditions

Modern Stochastics: Theory and Applications, 2019
In the paper we consider higher-order partial differential equations from the class of linear dispersive equations. We investigate solutions to these equations subject to random initial conditions given by harmonizable φ-sub-Gaussian processes.
Yuriy Kozachenko, Enzo Orsingher, Lyudmyla Sakhno, Olga Vasylyk   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Finding Structures of Interest in a Large Data Set Using Factor Analysis

Austrian Journal of Statistics, 2016
In this paper we introduce a statistical method which can be used in combination with principal component analysis or factor analysis. Certain variables of a large data set which are of interest can be selected in order to calculate loadings and scores ...
Peter Filzmoser
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

To save or not to save your family member’s life? Evolutionary stability of self-sacrificing life history strategy in monogamous sexual populations

BMC Evolutionary Biology, 2019
Background For the understanding of human nature, the evolutionary roots of human moral behaviour are a key precondition. Our question is as follows: Can the altruistic moral rule “Risk your life to save your family members, if you want them to save your
József Garay, Barnabás M. Garay, Zoltán Varga, Villő Csiszár, Tamás F. Móri   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Discovery of miR-mRNA interactions via simultaneous Bayesian inference of gene networks and clusters using sequence-based predictions and expression data

Journal of Integrative Bioinformatics, 2013
MicroRNAs (miRs) are known to interfere with mRNA expression, and much work has been put into predicting and inferring miR-mRNA interactions. Both sequence-based interaction predictions as well as interaction inference based on expression data have been ...
Godsey Brian
doaj   +2 more sources