Results 201 to 210 of about 3,790 (292)

Navigating End-of-Life Decisions With Amyotrophic Lateral Sclerosis: A Patient-Centered Perspective on the Clinical and Legal Barriers to Medical Aid in Dying. [PDF]

Cureus
Marie D, Miller LE, Bhattacharyya SK, Frankhauser FM.   +3 more
europepmc   +1 more source

Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants

Advanced Science, EarlyView.
A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei, Kai Zhang, Shuke Deng, Jinjie Chen, Xiaomei Huang, Jingfei Guo, Yuqing Wu, Yingjie Guo, Zhen Liang   +8 more
wiley   +1 more source

Ethical dilemmas in the care of patients with Alzheimer's disease and related dementias unable to give informed consent: positioning Lebanon within the Global North-South context. [PDF]

BMC Med Ethics
Al Mokdad Z, Msheik A, Tarabey L, Abou-Mrad F, Fadel P.   +4 more
europepmc   +1 more source

A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects

Advanced Science, EarlyView.
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha   +9 more
wiley   +1 more source

Ethical, legal, and social implications of AI-enabled digital therapeutics: A comparative analysis of risk-based regulatory frameworks in the European Union and Japan. [PDF]

Digit Health
Fukuda Y, Fukuda K.
europepmc   +1 more source

Hadamard Matrix Slicing Single‐Pixel Imaging: Establishing a Linear‐Array‐Inspired Paradigm for N‐fold Acceleration Single‐Pixel Imaging

Advanced Science, EarlyView.
To overcome two‐dimensional modulation bottlenecks, Hadamard Matrix Slicing Single‐Pixel Imaging (HMS‐SPI) establishes an efficient one‐dimensional imaging paradigm. By slicing the traditional Hadamard matrix into one‐dimensional encoding vectors and spatially expanding them, the required measurement patterns decrease by a factor of N.
Xiaoxue Li, Jieting Hou, Qizheng Zhao, Yiqi Jia, Xiang Zhong, Mengchao Ma, Huaxia Deng, Xinglong Gong, Ziwei Wang   +8 more
wiley   +1 more source

Governing AI in Mental Health: 50-State Legislative Review. [PDF]

JMIR Ment Health
Shumate JN, Rozenblit E, Flathers M, Larrauri CA, Hau C, Xia W, Torous EN, Torous J.   +7 more
europepmc   +1 more source

Neuromorphic Near‐Sensor and In‐Sensor Computing Enabled by Next‐Generation Material‐Based Sensors

Advanced Science, EarlyView.
This Review presents a structural framework that classifies neuromorphic sensing into near‐sensor and in‐sensor architectures, clarifying physical coupling between sensing and computation. The framework connects neural and synaptic device functions with recent advances in optical, mechanical, and chemical sensing, compares energy consumption and ...
Su Yeon Jung, Gwang Ya Kim, Sejin Kim, Hyunjong Seo, Se Gi Lee, Sang Min Won, Dongjoon Rhee, Joohoon Kang   +7 more
wiley   +1 more source

Toward a necessary right to self-representation in European civil law. [PDF]

Front Sociol
Rivero Silva S.
europepmc   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source