Results 31 to 40 of about 3,790 (292)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

LAS LEYES DE DESARROLLO BÁSICO DEL ESTATUTO DE AUTONOMÍA. EL CASO DE LA LEY DE GOBIERNOS LOCALES DE CATALUÑA [PDF]

Revista d'Estudis Autonòmics i Federals, 2009
The new Catalan Statute of Autonomy contains a novelty: detailed regulationsfor local government. These regulations require the appropriate legislativeimplementation.
Alfredo Galán Galán
doaj  

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

The basque statute of autonomy in the Spanish constitution

, 2015
> Basken sind ein faszinierendes Volk. Dies nicht nur deshalb, da sie eine Sprache sprechen, die mit keiner anderen genetisch verwandt ist und deshalb als isolierte Sprache bezeichnet werden kann, deren Ursprung bis heute nicht erforscht werden konnte ...
Hubmann, Robert
core   +2 more sources

Les autoritats lingüístiques

Revista de Llengua i Dret - Journal of Language and Law, 2006
Each of the languages declared to be official by the Constitution or Statutes of Autonomy has a language authority that has been recognized by the central government. These language authorities have adopted the model of the language academy.
Bartomeu Colom Pastor
doaj  

El Tribunal Constitucional como “supremo intérprete” de la Ley de Aguas [PDF]

Revista d'Estudis Autonòmics i Federals, 2011
In the STC 30/2011 nothing is as it should be, if viewed from a legal standpoint.The control of constitutionality over the Statute of Autonomy becomesa matter of plain legal control, twisting the line followed to date by theConstitutional Court to ...
Francisco Balaguer Callejón
doaj  

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

ELS DRETS ESTATUTARIS A LA SENTÈNCIA 31/2010, DE 28 DE JUNY, SOBRE LA REFORMA DE L'ESTATUT D'AUTONOMIA DE CATALUNYA [PDF]

Revista d'Estudis Autonòmics i Federals, 2011
The article analyzes the pronouncement of the STC 31/2010 about the foreseen rights to the Statute of 2006. Although he has refused that this the option is unconstitutional, its juridical foundation is incoherent and drives to a degradation of the ...
Marc Carrillo
doaj