Results 91 to 100 of about 321,647 (305)

ABOUT THE UNLIMITATION STATUTE ON APPEAL AGAINST LEVY OF EXECUTION BASED ON UNFAIR TERMS [PDF]

Challenges of the Knowledge Society
This paper aims to clarify the implications of the latest amendments made by the Romanian legislator in the field of unfair terms relating to the exercise of the right to appeal against levy of execution in Romanian civil law.
Mirel-Emanuel NEACȘU
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Timing of Challenges to Compel Critical Habitat Designation Under the Endangered Species Act: Should Courts Toll the General Federal Statute of Limitations? [PDF]

, 2009
The Secretary of the Interior, acting through the Fish and Wildlife Service, is directed by the Endangered Species Act to designate critical habitat concurrently with the listing of a species as endangered or threatened.
Crawford, Matthew D
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Issuing a Guilty Verdict With the Imposition of a Penalty and Certain Legal Aspects of Exemption From Its Execution [PDF]

Journal of Constitutional Law
The criminal procedural legislation exhaustively defines the legal grounds under which a court can issue a guilty verdict, impose a penalty, and later grant release from serving the sentence.
Lavrenti Maghlakelidze
doaj  

Dava Zamanaşımı Kaynaklı Adaletsizlik: Dava Zamanaşımı Süresinin Kanun Yolu Aşamasında Dolması Sonucunda Düşme Kararı Verilmesi

Ceza Hukuku ve Kriminoloji Dergisi
Ceza muhakemesinin nihai hedefi cezai uyuşmazlığın esasını çözmektir: Suç işleyen kişinin mahkûm edilmesiyle norm ihlalinin karşılıksız kalmadığını gören toplum ve suç mağduru olan birey tarafından ceza adalet sistemine duyulan kurumsal nitelikteki güven
İlhan Üzülmez, Gökhan Ölmez
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Life After Hardwick [PDF]

, 1992
Unless or until it is narrowed or overruled, Bowers v. Hardwick will dominate the law concerning government regulation of sexuality. In Hardwick the Supreme Court upheld as constitutional a Georgia sodomy statute that made oral or anal intercourse a ...
Hunter, Nan D.
core   +1 more source