Results 21 to 30 of about 2,022 (260)

LA POTESTAD SUBVENCIONAL EN EL ESTADO AUTONÓMICO [PDF]

Revista d'Estudis Autonòmics i Federals, 2008
The exercise of legal authority over subsidies by Public Authorities has beena permanent source of jurisdictional controversies on a constitutional scale.The persistence of conflicts relating to this is better understood at timeswhen a decrease in the ...
Luis Pomed Sánchez
doaj  

THE CONTEMPORARY BIOETHICAL TOWN: JONASIAN RESPONSIBILITY IN SOFT UNIVERSALISM

Revista Eletrônica do Curso de Direito da UFSM, 2018
Hans Jonas’s (1903-1993) thoughts and his imperative of responsibility is the cornerstone of this article, aiming the study of international and Brazilian legal statutes linked to bioethics.
Bruno Torquato de Oliveira Naves, Lorena Machado Rogedo Bastianetto   +1 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Derechos y libertades y Estado de las Autonomías

Revista Vasca de Administración Pública, 2010
The descentralization of Spain which began in the constituant process meant a new territorial model of State, in-between a federal State and a centralized one.
M.ª Isabel Álvarez Vélez, M.ª Fuencisla Alcón Yustas, Clara Martínez García   +2 more
doaj   +1 more source

LOS DEFENSORES DEL PUEBLO AUTONÓMICOS TRAS LA REFORMA DE LOS ESTATUTOS DE AUTONOMÍA [PDF]

Revista d'Estudis Autonòmics i Federals, 2008
The article examines the regulation on the autonomous-community ombudsmaninstitutions introduced by the recently approved statutes of autonomy.The article focuses the analysis on three dimensions of the ombudsman: itscompetences, its institutional status
Gerardo Ruiz-Rico Ruiz
doaj  

Sex, Sexuality, Sexual Offending and the Rights of Persons with Mental Disabilities

Laws, 2017
Although the legal issues related to sexual autonomy and sexual offending are significantly different, the resistance to providing adequate and effective counsel and the employment of the vividness heuristic (to privilege anecdote and reject valid and ...
Michael L. Perlin, Heather Ellis Cucolo, Alison J. Lynch   +2 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

LA SENTENCIA DEL TRIBUNAL CONSTITUCIONAL 247/2007 Y EL SISTEMA CONSTITUCIONAL DE DISTRIBUCIÓN DE COMPETENCIAS ENTRE EL ESTADO Y LAS COMUNIDADES AUTÓNOMAS [PDF]

Revista d'Estudis Autonòmics i Federals, 2008
The aim of this study is to examine articles 7 to 10 of ruling 247/2007 of theConstitutional Court, in which the role of the Statutes of Autonomy in thedivision of jurisdictions between the Central Government and the AutonomousCommunities is analysed ...
Joaquín Tornos Mas
doaj  

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source