Results 91 to 100 of about 20,918 (214)

Comparative analysis of the syncytiotrophoblast in placenta tissue and trophoblast organoids using snRNA sequencing

eLife
The syncytiotrophoblast (STB) is a multinucleated cell layer that forms the outer surface of human chorionic villi. Its unusual structure, with billions of nuclei in a single cell, makes it difficult to resolve using conventional single-cell methods.
Madeline M Keenen, Liheng Yang, Huan Liang, Veronica J Farmer, Rizban E Worota, Rohit Singh, Amy S Gladfelter, Carolyn B Coyne   +7 more
doaj   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

A primary cell‐based fluidic co‐culture model to investigate drug transport across the human placenta

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of a flow‐driven in vitro model of the human placental barrier designed to study transport processes during pregnancy. The model recreates key features of the maternal–fetal interface, enabling the investigation of how nutrients and therapeutic compounds cross the placental barrier under physiologically ...
Barbara Fuenzalida, Nadja Koechli, Edgar Ontsouka, Chennakesava Cuddapah, Martin Mueller, Bram Sengers, Frantisek Staud, Christiane Albrecht   +7 more
wiley   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Pharmacological studies on STb heat-stable enterotoxin in pig and rat jejunum

, 1989
The effects of Eschericihia coli heat-stable enterotoxin, STb, on the jejunum of pigs (three to six weeks old) and rats (250 to 350 g) were examined. In vivo and in vitro techniques consisting of ligated loops, perfused segments and isolated enterocytes ...
Kunkle, Bruce
core   +1 more source

Family Instability and Female Justice System Involvement: Reinterpreting the Impact of Legalized Abortion on Crime

Sociological Inquiry, Volume 96, Issue 4, 2026.
Female offending has profound familial and societal consequences, yet its distinct pathways remain understudied. Social control theory posits that female delinquency is more sensitive to familial relations and parental supervision than male delinquency (Worthen, Deviant Behavior, 2012, 33, 282).
Nora H. Lannert
wiley   +1 more source

Trophoblast Extracellular Vesicles Rewire Immunity: A Symptom‐Relief Avenue for Recessive Dystrophic Epidermolysis Bullosa

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
First‐trimester trophoblast EVs are enriched in anti‐inflammatory proteins, lipids, and immunoregulatory miRNAs. EVT‐EVs reprogram monocytes toward a pro‐resolving phenotype and restore immune homeostasis in RDEB, supporting their potential as offering a scalable off‐the‐shelf therapy for chronic inflammatory diseases.
Nell Hirt, Enzo Manchon, Ming Wu, Helene Le Buanec, Pauline Bataille, Emmanuelle Bourrat, Jean‐David Bouaziz, Nabila Jabrane‐Ferrat, Reem Al‐Daccak   +8 more
wiley   +1 more source

Identification of resistance sources and genomic regions regulating Septoria tritici blotch resistance in South Asian bread wheat germplasm

The Plant Genome
The Septoria tritici blotch (STB) [Zymoseptoria tritici (Desm.)] of wheat (Triticum aestivum L.) is characterized by its polycyclic and hemibiotrophic nature. It is one of the most dangerous diseases affecting wheat production worldwide.
Manjeet Kumar, Xinyao He, Sudhir Navathe, Umesh Kamble, Madhu Patial, Pawan Kumar Singh   +5 more
doaj   +1 more source

Assessment of Wind‐Farm‐Atmosphere Interactions at the Sørlige Nordsjø II Large Offshore Wind Farm: A Comparative LES and Analytical Wake Study

Wind Energy, Volume 29, Issue 10, October 2026.
ABSTRACT Sørlige Nordsjø II (SNII) is a planned large‐scale offshore wind farm in the Southern Norwegian North Sea near the Danish border, with phased development targeting a total installed capacity of up to 3 GW. For projects of this scale, site assessments are typically performed using computationally efficient analytical models.
Mostafa Bakhoday Paskyabi, Xu Ning
wiley   +1 more source