Results 141 to 150 of about 876,562 (293)

Spontaneous Dynamics of Asymmetric Random Recurrent Spiking Neural Networks

, 2004
We study in this paper the effect of an unique initial stimulation on random recurrent networks of leaky integrate and fire neurons. Indeed given a stochastic connectivity this so-called spontaneous mode exhibits various non trivial dynamics.
Beslon, G., Mazet, O., Soula, H.
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Overview of recent experimental results on the EAST Tokamak

Nuclear Fusion
Since the last IAEA-FEC in 2021, significant progress on the development of long pulse steady state scenario and its related key physics and technologies have been achieved, including the reproducible 403 s long-pulse steady-state H-mode plasma with pure
X. Gong, on behalf of EAST Team and Collaborators, The EAST Team:, Yuntao Song, Baonian Wan, Jiangang Li, Yuanxi Wan, Xinchao Wu, Fukun Liu, Junling Chen, Jiansheng Hu, Guosheng Xu, Kun Lu, Xianzu Gong, Bingjia Xiao, Yu Wu, Xiang Gao, Damao Yao, Nong Xiang, Liqun Hu, Chundong Hu, Jiefeng Wu, Biao Shen, Ge Gao, Yiyun Huang, Liuwei Xu, Qiyong Zhang, Cheonho Bae, Bin Cao, Lei Cao, Jiafeng Chang, Dalong Chen, Ran Chen, Xiaojiao Chen, Yebin Chen, Yue Chen, Yunxin Cheng, Yong Cheng, Bojiang Ding, Fang Ding, Rui Ding, Shijun Du, Yanmin Duan, Jia Fu, Daming Gao, Wei Gao, Yongqi Gu, Bin Guo, Fei Guo, Yong Guo, Xiaofeng Han, Shiying He, Ailan Hu, Chang Hu, Guanghai Hu, Huaichuan Hu, Qingsheng Hu, Yanlan Hu, Zhenhua Hu, Juan Huang, Liansheng Huang, Ming Huang, Ronglin Huang, Xiang Ji, Hua Jia, Caichao Jiang, Yinxian Jie, Songqing Ju, Defeng Kong, Erzhong Li, Guoqiang Li, Jiahong Li, Junjun Li, Miaohui Li, Pan Li, Kedong Li, Shi Li, Yadong Li, Lizhen Liang, Yanchuan Liao, Shiyao Lin, Xin Lin, Bili Ling, Haiqing Liu, Huajun Liu, Jianwen Liu, Liang Liu, Shaocheng Liu, Sheng Liu, Wenbin Liu, Xiaoju Liu, Xiaoyan Liu, Yong Liu, Zhihong Liu, Zhimin Liu, Jianhua Lu, Zhengping Luo, Dengkui Ma, Huafeng Mao, Wendong Ma, Songtao Mao, Yuzhou Mao, Tingfeng Ming, Chao Pan, Chengkang Pan, Shengmin Pan, Jing Qian, Jinping Qian, Chengming Qin, Zhiyong Qiu, Qilong Ren, Zhicai Sheng, Shihua Song, Pengjun Sun, Xiaoyang Sun, Youwen Sun, Tian Tang, Ling Tao, Ang Ti, Baoguo Wang, Feng Wang, Fudi Wang, Huihui Wang, Jian Wang, Liang Wang, Linsen Wang, Mao Wang, Ping Wang, Xiaojie Wang, Shouxin Wang, Yating Wang, Yuehang Wang, Yong Wang, Zhengchu Wang, Jianglong Wei, Jing Wei, Xuechao Wei, Bin Wu, Dajun Wu, Hao Wu, Jinhua Wu, Xiangming Wu, Yibing Wu, Zege Wu, Weibin Xi, Tianyang Xia, Yezheng Xiao, Yahong Xie, Yuanlai Xie, Handong Xu, Liqing Xu, Liuwei Xu, Weiye Xu, Ning Yan, Rong Yan, Jianhua Yang, Lei Yang, Qingxi Yang, Yao Yang, Zhongshi Yang, Min Yu, Yaowei Yu, Qiping Yuan, Shuai Yuan, Qing Zang, Bin Zhang, Jian Zhang, Jizong Zhang, Liyuan Zhang, Ling Zhang, Ruirui Zhang, Shoubiao Zhang, Tao Zhang, Wei Zhang, Xinjun Zhang, Xiuqing Zhang, Yang Zhang, Zuchao Zhang, Hailin Zhao, Lianmin Zhao, Guoqiang Zhong, Ruijie Zhou, Haishan Zhou, Tianhu Zhou, Yue Zhou, Dahuan Zhu, Haisheng Zhu, Ping Zhu, Zeying Zhu, Huidong Zhuang, Zibo Zhou, Zhiyong Zhou, Zhiwei Zhou, Guizhong Zuo, International and Domestic Collaborators:, Huishan Cai, Weixing Ding, Tao Lan, Adi Liu, Wandong Liu, Shaojie Wang, Minyou Ye, Yi Yu, Ge Zhuang, Wei Chen, Guangjiu Lei, Lin Nie, Min Xu, Huang Yuan, Nanhua Yao, Zhe Gao, Long Zeng, Tieshuan Fan, Liu Chen, Guoyong Fu, Zhiwei Ma, Zengmao Sheng, Yong Xiao, Xiaogang Wang, Zhongyong Chen, Yonghua Ding, Xiwei Hu, Zijiang Wang, Fangchuan Zhong, Hongbin Ding, Dezhen Wang, Zhengxiong Wang, Chenggang Jin, Xuemei Wu, Xiaofei Yang, Jianhua Zhang, Qingyuan Hu, Xi Yuan, Changqi Chen, Shuyi Gan, Xudi Wang, Congzhong Wu, Chongwei Zhang, Ting Zhang, Wu Zhu, Erhua Kong, Kaisong Wang, Chuanli Wang, Hongtao Yang, Lixiang Zhang, Yuhong Xu, Paul Anderson, Gheni Abla, Vincent Chan, John L. Doane, Andrea Garofalo, Punit Gohil, Chung Lih Hsieh, Ruey Hong, David Humphreys, Alan Walter Hyatt, Gary Jackson, Lang Lao, Yueqiang Liu, James Leuer, John Lohr, Mohamad Ali Mahdavi, Robert Olstad, Ben Penaflor, Ron Prater, David Piglowski, Michael Schaffe, Tim Scoville, Wayne Solomon, Mike Walker, Anders Welander, Manfred Bitter, Robert Budny, Robert A. Ellis, Nat Fisch, Rich Hawryluk, Kenneth W. Hill, Joel Hosea, Michael A. Jaworski, Egemen Kolemen, Rajesh Maingi, Dennis Mansfield, Dana M. Mastrovito, Jonathan Menard, Dennis Mueller, Novmir Pablant, Lane Roquemore, Filippo Scotti, Gary Taylor, Kevin Tritz, Randy Wilson, Michael Zarnstorff, Seung Gyou Baek, Beck Bill, Paul T. Bonoli, Robert Granetz, Ron Parker, Shunichi Shiraiwa, Josh Stillerman, Greg Wallace, Stephen Wukitch, Lihua Zhou, He Huang, Kenneth Gentle, Ken Liao, Perry Philippe, William L. Rowan, Linjin Zheng, Patrick H. Diamond, George R. Tynan, Nicolas Fedorczak, Peter Manz, Lei Zhao, David Brower, William W. Heidbrink, Yubao Zhu, Calvin W. Domier, Neville C. Luhmann, Chris Holcomb, Xueqiao Xu, Eric Wang, Max E. Fenstermarcher, Mickey Wade, Donald L. Hillis, Steve Meitner, Mickey Wade, Igor V. Vinyar, Vladimir Davydenko, Igor Shikhovtsev, Naoko Ashikawa, Kasahara Hiroshi, Katsumi Ida, Shinichiro Kado, Tomita Kawamura, Saito Kenji, Ryuhei Kumazawa, Ogawa Kunihiro, Isobe Mitsutaka, Shigeru Morita, Haruhisa Nakano, Masaki Osakabe, Mizuki Sakamoto, Yasuhiko Takeiri, Kazuo Toi, Katsuyoshi Tsumori, Nobuta Yuji, Masaya Hanada, Mitsuru Kikuchi, Atsushi Kojima, Kazuhiro Watanabe, Jean-Francois Artaud, Vincent Basiuk, F. Bouquey, B. Bremond, Laurent Colas, Joan Decker, D. Douai, Annika Ekedahl, Christel Fenzi, Eric Gauthier, Gerardo Giruzzi, Marc Goniche, Dominique Guilhem, Walid Helou, Julien Hillairet, Tuong Hoang, Philippe Huynh, Frederic Imbeaux, Xavier Litaudon, Roland Magne, Yves Peysson, K. Vueillie, Xiaolan Zou, Alberto Loarte, Richard Pitts, Tom Wauters, Franz Braun, R. Bilato, Volodymyr Bobkov, J.M. Noterdaeme, Qingquan Yu, Yunfeng Liang, Jonny Pearson, Michael Rack, Joseph Banks, John Fessey, Charles Monroe, Damian King, Stefan Schmuck, Hongjuan Sun, Paul Trimble, Tom Todd, Jun-Gyo Bak, Suk-Ho Hong, Sangong Lee, Bae Young Soon, Oh Byung Hoon, Chang Doo Hee, Lee Kwang Won, Luca Amicucci, Giuseppe Calabro, Silvio Ceccuzzi, Roberto Cesario, Flavio Crisanti, Edmondo Giovannozzi, Giuseppe Ramogida, Gianmaria De Tommasi, Angelo Antonio Tuccillo, Bruno Viola, Raffaele Albanese, Roberto Ambrosino, Lucio Barbato, Stefano Mastrostefano, Alfredo Pironti, Vincenzo Pericoli Ridolfini, Rory Scannell, Fabio Villone, Volker Naulin, Anders H. Nielsen, Roman Zagorsky, Sandor Zoletnik, Chijin Xiao, B. Madsen, M. Salewski, Eugenio Schuster   +424 more
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source