Results 121 to 130 of about 597,820 (311)
, 2016 Undecaprenyl pyrophosphate synthase (UPPs) catalyzes the condensation of eight molecules of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to generate C55 undecaprenyl pyrophosphate.
Shean-Tai Chiou (2945166) +2 more
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2012 One of the aims of the European Directive 2010/31/EU (formerly 2002/91/EC) is to reduce the energy consumption of buildings introducing an energy labeling protocol which is expected to capture the attention and reorient the market, sustaining the ...
Gasparella, Andrea, Pernigotto, Giovanni
core
Analysis for TCSC Steady-State Characteristics
, 2011 When the TCSC steady-state operation, the thyristor turn-on and turn-off time is definite, the changing for TCSC electric capacity voltage and thyristor electric current is with the periodicity and symmetry.Thyristor controlled series compensation ...
Xiang Jie Chen, Ying Chen
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Steady State Analysis of Phosphorylated afRio1.
, 2012 Steady State Analysis of Phosphorylated afRio1.
Irene N. Kiburu (163639) +1 more
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Steady-state and transient operation discrimination by Variational Bayesian Gaussian Mixture Models
, 2013 The paper presents a Variational Bayesian (VB) method to allow a Gaussian Mixture Model (GMM) to be clustered automatically with its mixture components in order to facilitate the discrimination of what can be regarded as steady-state and transient ...
Yu Zhang (17170738) +3 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source