Results 91 to 100 of about 19,322,673 (300)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Feed and Bleed Operating Mode for Electrochemical Flow Cells: Challenges, Solutions and Practical Insights

ChemElectroChem
Electrochemical processes offer promising routes to defossilize the chemical industry by integrating low‐carbon electricity. However, bridging the gap between lab‐scale experimental studies and pilot‐scale industrial applications is still challenging ...
Jonas Baessler, Malte Wehner, Mojtaba Mohseni, Julian Neumann, Matthias Wessling, Robert Keller   +5 more
doaj   +1 more source

Thermomechanical analysis of UO2 fuel rods with SiC_f/SiC composite cladding under normal and accident conditions

Nuclear Engineering and Technology
To assess the mechanical response and structural integrity of fuel cladding under high-temperature conditions, a two-dimensional axisymmetric finite-element model of a UO2–SiC composite cladding system was developed.
Yuyang Zhao, Qin Zeng, Zhiwei Lu, Jiye Zheng, Jiaxiang Xue, Yehong Liao   +5 more
doaj   +1 more source

Concurrent operation of 10 gyrotrons at W7-X experience and improvement opportunities

EPJ Web of Conferences, 2018
At the stellarator Wendelstein 7-X (W7-X) Electron Cyclotron Resonance Heating (ECRH) is the main heating system for steady-state operation and was the only available heating system during the operation phase OP1.2a in 2017.
Braune H., Brunner K.J., Laqua H.P., Marsen S., Moseev D., Noke F., Purps F., Schneider N., Schulz T., Stange T., Uhren P., Wilde F.   +11 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Operation control and mode adaptive switching strategy for low-voltage flexible DC interconnection systems

电力工程技术
Low-voltage flexible direct currect (LV-FDC) technology represents a vital technical approach to addressing the issues of heavy overloading and power supply reliability in end-user distribution networks.
Changjun JIANG, Haitao LIU, Xiong XIONG, Changhao GUO   +3 more
doaj   +1 more source

Steady State Tokamak Sustained by Bootstrap Current Without Seed Current [PDF]

, 1992
Steady state tokamak solution is studied by taking into account the current diffusivity. The seed current for generating the Bootstrap current is supplied through the radial diffusion of the Bootstrap current.
Itoh, S.-I., Itoh, K., Fukuyama, A.
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Model, Characterization, and Analysis of Steady-State Security Region in AC/DC Power System with a Large Amount of Renewable Energy

Energies, 2017
A conventional steady-state power flow security check only implements point-by-point assessment, which cannot provide a security margin for system operation.
Zhong Chen, Hui Chen, Minhui Zhuang, Siqi Bu   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source