Results 111 to 120 of about 1,254,219 (267)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Rolling work and power in high-speed finishing blocks of wire mills

Литьë и металлургия, 2001
It is shown that with real drawing-down coefficients used in stand finishing blocks at hot rolling of steel wire rod the rolling speeds when metal can break in strand exit plane are impossible to reach in practice.
V. V. Fillippov, A. A. Gorbanev, S. M. Zhuchkov, V. A. Tischenko, A. B. Steblov   +4 more
doaj  

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Influence of distribution of metal density within width of roller transporter on uniformity of rolled wire laps chilling

Литьë и металлургия, 2002
There is analysed the influence of distribution of metal density within width of transporter on uniformity of rolled wire chilling. The ways of increasing of uniformity of structure and characteristics of rolled wire by length of hanks are offered.
S. M. Zhuchkov, V. V. Filippov, A. A. Gorbanev, V. A. Tishchenko, A. B. Steblov   +4 more
doaj  

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Estimation of influence of uniflow closed-bottom thimbles on subshrinking liquidation

Литьë и металлургия, 2002
There is developed the technology of steel cast at MNLZ- 3 with protection of metal stream against secondary oxidation in zone flushing bowl-crystallizer through closed-bottom quartz immersible thimbles.
E. V. Ivanov, A. V. Olenchenko, M. E. Kontanistov, A. I. Nosovets   +3 more
doaj  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Ductile and scalable 3 GPa steel via a hierarchical microstructural architecture

Nature Communications
Ultrahigh-strength steels with yield strengths exceeding 3 GPa and appreciable ductility represent a transformative frontier in materials science. Conventional strengthening approaches, such as cold-work hardening, however, inevitably trade strength for ...
Ruming Geng, Yue Liu, Peiwen Tang, Xiaoyuan Yuan, Leilei Li, Yu Liu, Hanqi Wang, Lijing Zheng, Simin Lei, Yandong Sun, Yuxian Cao, Xinyang Li, Shun Han, Yong Li, Robert O. Ritchie, Shiteng Zhao, Huibin Xu, Chunxu Wang   +17 more
doaj   +1 more source

High strength structural steel at elevated temperatures

, 2006
This paper presents the mechanical properties of high strength structural steel and mild structural steel at elevated temperatures. Mechanical properties of structural steel at elevated temperatures are important for fire resistant design of steel ...
Young, Ben, Uy, Brian, Chen, Ju
core  

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source