Results 251 to 260 of about 72,571 (307)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

The Preparation of Robust Gully-like Surface of Stainless Steel Fiber-Bonded TFPA-TTA-COF with Nano Pores for Solid-Phase Microextraction of Phenolic Compounds in Water. [PDF]

Nanomaterials (Basel)
Wei W, Shi Y, Zhang K, Li B.
europepmc   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Study on the effect of rubber content on the frost resistance of steel fiber reinforced rubber concrete. [PDF]

Sci Rep
Jiang L, Jing J, Zhang M, Yang S.
europepmc   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Study on Shear Performance of Corroded Steel Fiber Reinforced Concrete Beams under Impact Load. [PDF]

Materials (Basel)
Gu J, Li L, Huang X, Chen H.
europepmc   +1 more source

Novel sustainable steel fiber reinforced preplaced aggregate concrete incorporating Portland limestone cement. [PDF]

Sci Rep
Saleh MA, Su Z, Zhang J.
europepmc   +1 more source

Research on Compression Failure Characteristics and Damage Constitutive Model of Steel Fiber-Reinforced Concrete with 2% Copper-Coated Fibers Under Impact Load. [PDF]

Materials (Basel)
Liu G, Bai Z, Liu W, He Y.
europepmc   +1 more source

A Novel Gully-like Surface of Stainless-Steel Fiber Coated with COF-TPB-DMTP Nanoparticles for Solid-Phase Microextraction of Phthalic Acid Esters in Bottled Tea Beverages. [PDF]

Nanomaterials (Basel)
Yuan Y, Li B, Zhang K, Zhu H.
europepmc   +1 more source

Reinforcement Effects on Tensile Behavior of Ultra-High-Performance Concrete (UHPC) with Low Steel Fiber Volume Fractions. [PDF]

Materials (Basel)
Luo X, Zhang S, Li A, Zhang C, Zhang Y.
europepmc   +1 more source