Results 171 to 180 of about 47,365 (264)

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

open access: yesAdvanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi   +7 more
wiley   +1 more source

Development of Kilogram-Scale Electrochemical Ni-Catalyzed Cross Electrophile Coupling in Flow. [PDF]

open access: yesOrg Process Res Dev
Kelly M   +7 more
europepmc   +1 more source

Sustained Self‐Powered Real‐Time Vibration Monitoring Through Integrated Nonlinear Harvesting and Energy‐Aware Wireless Sensing

open access: yesAdvanced Science, EarlyView.
A self‐powered vibration sensing platform integrates a quasi‐zero‐stiffness piezoelectric harvester, synchronized electric charge extraction, energy management, and wireless ADC acquisition. Ambient vibration is simultaneously harvested as energy and digitized as information, enabling sustained real‐time waveform monitoring without external power.
Yizhou Li   +10 more
wiley   +1 more source

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

open access: yesAdvanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang   +5 more
wiley   +1 more source

Sonoselective Transfection of Glioma Endothelium

open access: yesAdvanced Science, EarlyView.
Delivering non‐viral, gene‐bearing nanoparticles with thiol‐decorated surfaces to gliomas with focused ultrasound yields transfection tropism for endothelial cells. From this platform, “sonoselective” transfection of glioma endothelium is achieved via incorporation of an endothelial cell‐specific promoter.
Anna C. Debski   +8 more
wiley   +1 more source

Receptogenesis in a Vascularized Robotic Embodiment

open access: yesAdvanced Science, EarlyView.
Functional augmentation of situated robots via ex novo hardware generation extends physical adaptability. Drawing inspiration from open circulatory systems for mass and function redistribution, this study presents a vascularized robotic composite exhibiting receptogenesis ‐ the on‐demand construction of sensors ‐ from internal fluid reserves based on ...
Kadri‐Ann Pankratov   +8 more
wiley   +1 more source

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