Results 41 to 50 of about 781,176 (308)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Numerical analysis-based evaluation of combustion and gasification characteristics of pulverized coal and coke in the raceway region

Fuel Processing Technology
Steelmaking is essential to modern society but remains a major CO₂ emitter. To mitigate this, technologies like hydrogen-based steelmaking and alternative reducing agents are being explored.
Hiroki Umetsu, Kenji Tanno, Toshiaki Fukada, Satoshi Umemoto, Kazuki Tainaka, Atsushi Ikeda, Kota Moriya, Akinori Murao, Hiroaki Watanabe   +8 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

A review of ordering phenomena in iron-silicon steels [PDF]

, 2013
Silicon steel is an industrially-desired alloy of iron and silicon, characterised by soft magnetic properties, low eddy-current losses, and low magnetostriction.
González Cámara, Fernando, Houbaert, Yvan   +1 more
core   +3 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Microstructural Organization and Mechanical Properties of 5356 Aluminum Alloy Wire Arc Additive Manufacturing Under Low Heat Input Conditions

Metals
This study examines the microstructure and mechanical properties of 5356 aluminum alloy under low heat input conditions during arc additive manufacturing, focusing on the challenges posed by excessive heat input, which hinders specimen formation and ...
Xiaogang Zuo, Zhimin Lv, Yuejie Wang, Xiaokang Chen, Wenjun Qi   +4 more
doaj   +1 more source

Levelized Cost Analysis for Blast Furnace CO₂ Capture, Utilization, and Storage Retrofit in China’s Blast Furnace–Basic Oxygen Furnace Steel Plants

Energies, 2023
As the largest carbon emitter in China’s manufacturing sector, the low-carbon transition of the steel industry is urgent. CO2 capture, utilization, and storage (CCUS) technology is one of the effective measures to reduce carbon emissions in steel ...
Changwan Gu, Jingjing Xie, Xiaoyu Li, Xu Gao   +3 more
doaj   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Synergistic effect of oxygen-rich and hydrogen-rich blast on gas phase in the lower part of blast furnace

Heliyon
The BF(blast furnace) process has become the most powerful pointcut for energy conservation and emission reduction in the iron and steel industry. Few researchers have studied the composition and distribution of bosh gas with co-injection of pulverized ...
Tao Li, Fangqin Shangguan, Guangwei Wang, Cuiliu Zhang, Desheng Li   +4 more
doaj   +1 more source