Results 41 to 50 of about 1,947,864 (315)

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Seismic Evaluation of Steel Moment Frames Rehabilitated with CBF, EBF and BRBF Braced Systems [PDF]

مجله مدل سازی در مهندسی, 2017
Many of the existing buildings are made and designed in according to Standard No.2800 (1st Edition). in recent years Increasing in earthquake engineering knowledge and changing in design criteria regulations and seismic evaluation has caused that the ...
Morteza Raissi Dehkordi, Morteza Alizadeh, Mahdi Eghbali   +2 more
doaj   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Retrofitting Steel Moment Frames by Using the Cable Bracing

Journal of Building Material Science, 2019
In this paper, the behavior of retrofitted steel moment frames with bracing has been investigated. Braces include double-channel cross brace, cross braces with cable and brace with two cables passed through a cylindrical steel sheath at the location of the cables.
openaire   +1 more source

Factors Associated With Fibromyalgia Diagnosis Among People Meeting Criteria: Results From UK Biobank

Arthritis Care &Research, EarlyView.
Objective The diagnosis of fibromyalgia (FM) is challenging due to the absence of definitive biomarkers, numerous overlapping comorbidities, and its reliance on patient‐reported symptoms. Discrepancies between diagnostic criteria and clinical practice imply the possibility of diagnostic biases, complicating timely and accurate identification.
Sung‐A Kim, Gary J. Macfarlane, Marcus J. Beasley   +2 more
wiley   +1 more source

Seismic performance evaluation of Egyptian code-designed steel moment resisting frames

HBRC Journal, 2018
Despite the fact that steel is a ductile material, the significant damage, during earthquake events, highlighted the need to thoroughly investigate the seismic performance of steel structures.
Mohammed H. Serror, Mohammed N. Abdelmoneam   +1 more
doaj   +1 more source

Match Compliance of Conventional Design Codes with Instructions for Seismic Rehabilitation of Buildings in Performance Evaluation of Steel Moment Frames [PDF]

Journal of Structural and Construction Engineering, 2019
Today, instructions for seismic rehabilitation of existing buildings are widely used for seismic performance evaluation of existing buildings. Moreover, nonlinear structural analysis methods are permitted for seismic design of new buildings in recent ...
M. A. Najafgholipour, M.A. Hadianfard, sh malekjamshidi, Seyed Mehdi Dehghan   +3 more
doaj   +1 more source

Ensuring the Safety of Steel Moment Frames Subjected to Uncertain Impacts

Buildings, 2023
The article addresses the problem of safety evaluation of steel moment frames of civil buildings, e.g., warehouses, shops, garages, and multistory industrial buildings on deformable soil in the relevant case of an emergency impact. The case of accidental
Anatoly Victorovich Alekseytsev
doaj   +1 more source

Comparative Study of Diagrid Moment Resisting Steel Frame Structure with Conventional Braced Moment Resisting Steel Frame Structure

, 2016
The rapid growth of tall and slender buildings in modern cities demands structurally efficient systems that can simultaneously ensure strength, stiffness, and architectural freedom. Traditional Conventional Braced Moment Resisting Steel Frames (CBMRF), though widely adopted, often face limitations in controlling lateral drift and optimizing material ...
Chirag Ka Patel, Patel Manish
openaire   +2 more sources