Results 211 to 220 of about 96,811 (268)
Advanced Science, EarlyView.Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn +20 more
wiley +1 more source
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
Friend, Not Foe: Lowered Tissue Reactivity to Long‐Term Polyimide Implants
Advanced Science, EarlyView.The choice of optimal neural probe designs remains a major challenge in the field of neurotechnology. This study investigated the biocompatibility of several probe variations, including material, thickness, width, and implantation strategy. It highlights the clear advantage of soft polyimide probes over stiff silicon probes for better device ...
Corinne Orlemann +11 more
wiley +1 more source
Advanced Science, EarlyView.Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters +12 more
wiley +1 more source
Advanced Science, EarlyView.Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang +3 more
wiley +1 more source
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Progress in Structural Engineering and Materials, 2001
AbstractSteel plated structures are important because they are used in large structures of vital importance for society. For the steel construction industry they are however of less importance as they are a small part of the turnover. Since the big disasters with box girder bridges more than thirty years ago very little money, public or private, has ...
Bernt Johansson, Milan Veljkovic
openaire +1 more source
AbstractSteel plated structures are important because they are used in large structures of vital importance for society. For the steel construction industry they are however of less importance as they are a small part of the turnover. Since the big disasters with box girder bridges more than thirty years ago very little money, public or private, has ...
Bernt Johansson, Milan Veljkovic
openaire +1 more source
Metals Technology, 1975
AbstractThis paper deals with the basic principles of the production of mild steel plates in reversing plate mills. These plates are presented to the customer after shearing or gas cutting to the ordered size. The notes deal necessarily with existing British practices and combine desirablefeatures of the existing five reversing plate mills within the ...
openaire +1 more source
AbstractThis paper deals with the basic principles of the production of mild steel plates in reversing plate mills. These plates are presented to the customer after shearing or gas cutting to the ordered size. The notes deal necessarily with existing British practices and combine desirablefeatures of the existing five reversing plate mills within the ...
openaire +1 more source
1995
This volume strives to give comprehensive information about the main aspects of the behaviour and limit states of steel plated structures. In following this objective, the volume presents a complete scientific background (profiting from the fact that the authors of the individual parts of the publication have personally been very active in the ...
openaire +1 more source
This volume strives to give comprehensive information about the main aspects of the behaviour and limit states of steel plated structures. In following this objective, the volume presents a complete scientific background (profiting from the fact that the authors of the individual parts of the publication have personally been very active in the ...
openaire +1 more source