Results 191 to 200 of about 278,365 (386)

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

open access: yesAdvanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie   +8 more
wiley   +1 more source

Counterbalancing O‐GlcNAcylation and STAT3 Phosphorylation in Ventral Tegmental Area Dopaminergic Neurons Mediates Behavioral Adaptations to Acute Restraint Stress

open access: yesAdvanced Science, EarlyView.
Acute restraint stress enhances STAT3Ser727 phosphorylation in dopaminergic neurons in mice. This modification promotes the upregulation of GABBR2 and GABRB3, reduces neuronal activity, and contributes to anxiety‐like behavior and diminished reward‐seeking following stress exposure.
Mingshuo Shao   +10 more
wiley   +1 more source

Design of steel sheathed cold-formed steel framed shear walls

open access: green, 2013
N. Balh   +5 more
openalex   +2 more sources

Sparse Nanocrystals Enable Ultra‐Low Coercivity and Remarkable Mechanical Robustness in High‐Entropy Amorphous Alloy

open access: yesAdvanced Science, EarlyView.
An order modulation strategy is introduced to overcome trade‐off between mechanical and magnetic properties by constructing an amorphous‐nanocrystalline transitional structure in a ferromagnetic HEA system. This enable the resultant alloys to combine an ultra‐low coercivity of 0.3 A m−1 with a remarkable mechanical toughness, thereby achieving a ...
Lichen Liu   +8 more
wiley   +1 more source

Theranostic Toolbox for Neutrophil Functionalization

open access: yesAdvanced Science, EarlyView.
Here, neutrophil‐specific fluorine nanoparticles additionally equipped with either activating or inhibiting peptides for a background‐free 19F MRI‐based nanotheranostic approach are engineered. It is demonstrated that this approach is suitable to visualize and concomitantly direct neutrophil functionality depending on the specific requirements to ...
Pascal Bouvain   +11 more
wiley   +1 more source

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