Results 71 to 80 of about 2,880 (298)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Steganography using cylinder insertion algorithm and mobile based stealth steganography [PDF]

, 2010
Title from first page of PDF file (viewed January 3, 2011)Includes bibliographical references (p. 41-42)Steganography provides methods for concealing secret information from third parties.
Patel, Leezaben Ashokkumar
core  

Data hiding inside JPEG images with high resistance to steganalysis using a novel technique: DCT-M3

Ain Shams Engineering Journal, 2018
Information security relies mainly upon encryption, and in some cases, steganography for an extra layer of security. Steganography is the science and art of secret communication between two sides that attempts to conceal the existence of the message ...
Abdelhamid Awad Attaby, Mona F.M. Mursi Ahmed, Abdelwahab K. Alsammak   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Steganography algorithm to hide secret message inside an image [PDF]

, 2011
In this paper, the authors propose a new algorithm to hide data inside image using steganography technique. The proposed algorithm uses binary codes and pixels inside an image.
Teoh, Suk Kuan, Ibrahim, Rosziati
core  

Novel Technique for Securing Data Communication Systems by Using Cryptography and Steganography [PDF]

Jordanian Journal of Computers and Information Technology, 2017
The information security becoming more important and attracting much attention nowadays as the number of data being exchanged over the internet increased.
Walaa H. Al-qwider, Jamal N. Bani Salameh   +1 more
doaj   +1 more source

An Improved Image Steganography Algorithm Based on PVD

Indonesian Journal of Electrical Engineering and Computer Science, 2018
In this paper, a modification of PVD (Pixel value differencing) algorithm is used for Image Steganography in spatial domain. It is normalizing secret data value by encoding method to make the new pixel edge difference less among three neighbors (horizontal, vertical and diagonal) and embedding data only to less intensity pixel difference areas or ...
Sharif Shah Newaj Bhuiyan, Norun Abdul Malek, Othman Omran Khalifa, Farah Diyana Abdul Rahman   +3 more
openaire   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source