Results 101 to 110 of about 1,392 (257)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
MSE_LSB Method of Message Steganography
International Journal of Computer Science and Mobile ComputingA modified, secure and efficient LSB based method (MSE_LSB) of message steganography will be introduced. The single character of the secret message will be hidden in spaced covering bytes. The covering-stego bytes will be reordered and scattered based on the contents of the generated secret indices key, this key will be used to reorder and reorder back
openaire +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A Study of Text Steganography Methods [PDF]
Journal of Engineering and Applied Sciences, 2019 Fitra Chairil Akbar +2 more
openaire +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
MAE-based image inpainting-steganography method
CybersecurityAbstract To address the current issue that existing steganographic techniques are highly dependent on the quality of carrier images and have insufficient adaptability to damaged images, we propose an MAE-based inpainting-steganography framework, which realizes steganography and inpainting for 2D color damaged images through multi ...
Chunying Zhang +5 more
openaire +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Steganography using Syntactic Method
Al-Qadisiyah Journal of Pure Science, 2023 Saad Nasser Al.Azzam, Fahad Ali Al-Qarni
openaire +1 more source