Results 161 to 170 of about 1,888 (254)

A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex. [PDF]

Science
Vuong CK, Weber A, Seong P, Matoba N, Chen YJ, Peyer J, Younesi S, Salinda A, Gomez D, Rivas G, Morales A, Shafie B, Zhang P, Nichterwitz S, Qi L, Fernandez NT, Friedman E, Love MI, Gandal MJ, Geschwind DH, Lowry WE, Stein JL, de la Torre-Ubieta L.   +22 more
europepmc   +1 more source

Mediation Analysis With Bayesian Nonlinear Joint Models: Evaluation of the Treatment Causal Pathways Between Tumor Growth Kinetics and Overall Survival

Statistics in Medicine, Volume 45, Issue 13-14, June 2026.
ABSTRACT Understanding the mechanisms through which anti‐cancer treatments influence survival is central to improving drug development and evaluation. In this work, we develop a Bayesian joint modeling framework for mediation analysis to quantify the extent to which tumor size dynamics mediate the effect of treatment on overall survival (OS). Our model
Georgios Kazantzidis, Francois Mercier, Virginie Rondeau   +2 more
wiley   +1 more source

The equilibrium point hypothesis revisited: why threshold control does not explain human movement. [PDF]

Exp Brain Res
Mangalam M, Stergiou N.
europepmc   +1 more source

Covariance Estimation for Wide Data

WIREs Computational Statistics, Volume 18, Issue 2, June 2026.
Covariance matrix estimation is fundamental to multivariate analysis, with applications spanning finance, genomics, climate science, and signal processing. This review synthesizes recent advances in high‐dimensional covariance estimation‐thresholding, linear and nonlinear shrinkage, graphical models, and random matrix theory‐under a unifying framework ...
Eran Raviv
wiley   +1 more source

Standardized Approach for Diversification of Complex Small Molecules via Aryl Thianthrenium Salts. [PDF]

J Am Chem Soc
Ahmadli D, Müller S, Xie Y, Smejkal T, Jaeckh S, Iosub AV, Williams SR, Ritter T.   +7 more
europepmc   +1 more source

Bayesian Full‐Waveform Monitoring of CO2 Storage With Fluid‐Flow Priors via Generative Modeling

Journal of Geophysical Research: Machine Learning and Computation, Volume 3, Issue 3, June 2026.
Abstract Quantitative monitoring of subsurface changes is essential for ensuring the safety of geological CO2 ${\text{CO}}_{2}$ sequestration. Full‐waveform monitoring (FWM) can resolve these changes at high spatial resolution, but conventional deterministic inversion lacks uncertainty quantification and incorporates only limited prior information ...
Haipeng Li, Nanzhe Wang, Louis J. Durlofsky, Biondo L. Biondi   +3 more
wiley   +1 more source

Systematic analysis of immune cell motility leveraging the open intravital microscopy database Immunemap. [PDF]

EMBO J
Pizzagalli DU, Carrillo-Barberà P, Bansal H, Palladino E, Ceni K, Thelen B, Pulfer A, Moscatello E, Fiamma Cabini R, Textor J, M N Wortel I, Immunemap Consortium, Krause R, Fernandez Gonzalez S.   +13 more
europepmc   +1 more source

Arc Heat Flow and Magmatic Heat Budgets

Reviews of Geophysics, Volume 64, Issue 2, June 2026.
Abstract We evaluate hydrothermal heat loss from 11 volcanic‐arc segments (∼6,000 km of arc length, ∼10% of the global total), motivated by the observation that much magmatic heat ultimately crosses the land surface as heated aqueous fluid. Heat loss takes place by volcanic eruption, geothermal heat conduction to the surface, fumarolic (vapor ...
S. E. Ingebritsen, Kazuki Sawayama, Yuri Taran, Giovanni Chiodini, Tsuneomi Kagiyama, Hiroshi Shinohara, Julie V. Rowland, Benjamin A. Black   +7 more
wiley   +1 more source

Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches. [PDF]

Immunity
Alouche N, Cannelle H, Favre S, Jokić M, Villegas JA, Maréchal S, De Nolf C, Delacrétaz M, Sifis A, Chapuis C, Burns A, Ambrosini G, Dupanloup I, Abe J, Koch U, Guex N, Stein JV, Maillard I, Cupedo T, Ludewig B, Radtke F, Janssens S, Luther SA.   +22 more
europepmc   +1 more source

ON THE INHOLOMORPHIC QUANTITY OF A REGION IN A STEIN MANIFOLD

Memoirs of the Faculty of Science, Kyushu University. Series A, Mathematics, 1962
openaire   +3 more sources