Results 171 to 180 of about 5,138 (231)

Small bowel lymphatic malformation: Clinical presentation and a comprehensive literature review. [PDF]

open access: yesWorld J Clin Oncol
Khalayleh H   +7 more
europepmc   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Refining the treatment of immune checkpoint inhibitor–associated myocarditis: Challenges, innovations and rechallenge considerations

open access: yesBritish Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu   +10 more
wiley   +1 more source

Discrete stochastic maximal regularity. [PDF]

open access: yesMath Ann
Evangelopoulos-Ntemiris F, Veraar M.
europepmc   +1 more source

Embodied practice in a disembodied time: How the COVID‐19 pandemic shaped direct work with children and young people

open access: yesChild &Family Social Work, EarlyView.
Abstract The COVID‐19 pandemic and related restrictions imposed in the UK had a significant impact on social work practice with children and young people. As has been widely reported, practitioners were deprived of multisensory information in their assessments and of opportunities to connect with children.
Heather Ellis, Ariane Critchley
wiley   +1 more source

We Guide Them to Independence. Experiences of Professionals Involved in the Transition to Adulthood of Unaccompanied Refugee Adolescents

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT The paper explores the experiences of professionals who support unaccompanied refugee adolescents in the Netherlands as they transition to adulthood. This study highlights a crucial yet understudied period for these young people, many of whom arrive at the age of 16 or older and have only a short period of time to become self‐sufficient before
L. N. Hacquebord   +3 more
wiley   +1 more source

Relational Wellbeing Amongst Care‐Experienced Young People in Transition in the Context of Covid 19

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT Care‐experienced young people typically negotiate the transition to adulthood at a younger age than their peers in the general population and with less reliable access to support. Concerns have been raised that Covid 19 exacerbated the challenges they faced and widened the ‘care‐gap’.
Emily R. Munro, Seana Friel, Amy Lynch
wiley   +1 more source

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