Results 61 to 70 of about 23,438 (217)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The µ Herculis system solved after nearly three centuries

Astronomy & Astrophysics
Context. µ Herculis is a bright, nearby quadruple system. Its brightest member, µ Her Aa, displays solar-like oscillations, establishing the system as a crucial benchmark for asteroseismology, provided that its mass can be determined independently of ...
Marcussen Marcus L., Lund Mikkel N., Grundahl Frank, Huber Daniel, Knudstrup Emil, Kraus Adam L., Baranec Christoph, Pallé Pere L., Dupuy Trent J., Huber Guillaume, Ou James, Werber Zach, Zhang Ruihan, Riddle Reed   +13 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Exploring central star variability of planetary nebulae using gaia photometry

Scientific Reports
This study presents an analysis of the variability of 81 central stars of planetary nebulae (CSPNe) are identified as variable in Gaia Data Release 3 (DR3).
M. A. NegmEldin, A. Ali, G. M. Hamid, A. Essam   +3 more
doaj   +1 more source

Evaluation of a pre-formulated post-emergence herbicide mixture of topramezone and dicamba on annual weeds and Bermuda grass in maize in a sub-tropical agro-ecology

Heliyon, 2019
Weed infestation is one of the major causes of low maize grain yield in sub-Saharan Africa (SSA). The perennial grass weed, Cynodon dactylon (L.) Pers., is one of the most problematic weeds in maize in SSA.
Justin Chipomho, Solomon Mupeti, Caroline Chipomho, Nilton Mashavakure, Arnold Bray Mashingaidze   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Benchmarking pre-main sequence stellar evolutionary tracks using disk-based dynamical stellar masses

Astronomy & Astrophysics
Stellar masses are a fundamental property to understand models of pre-main sequence evolution, but their values derived from Hertzsprung–Russell (HR) diagrams are strongly model dependent.
Zallio Luigi, Vioque Miguel, Andrews Sean M., Empey Aaron, Rosotti Giovanni P., Miotello Anna, Manara Carlo F., Carpenter John M., Deng Dingshan, Kurtovic Nicolás T., Law Charles J., Longarini Cristiano, Paneque-Carreño Teresa, Teague Richard, Villenave Marion, Yen Hsi-Wei, Zagaria Francesco   +16 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source