Results 151 to 160 of about 895,436 (365)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Cosmic abundances: The impact of stellar duplicity

, 2004
The mass-transfer scenario links chemical peculiarities with stellar duplicity for an increasing number of stellar classes (classical and dwarf barium stars, subgiant and giant CH stars, S stars without technetium, yellow symbiotic stars, WIRRING stars ...
Jorissen, A., Van Eck, S.
core   +1 more source

The abundance of helium and stellar pulsation

Astronomical & Astrophysical Transactions, 1998
Radial gradient of relative amplitude of the light variation FV for galactic classical Cepheids is found. The gradient has different signs for two cases: P > 8d and P < 8d. For P > 8d the gradient is negative. This gradient is caused by gradient of helium content in the primordial clouds, where Cepheids were born.
openaire   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Boron Abundances in Early B Dwarfs of the Galactic Open Cluster NGC 3293

The Astrophysical Journal
New boron abundances or upper limits have been determined for eight early B stars in the young Galactic open cluster NGC 3293, using UV spectra obtained by the Hubble Space Telescope Cosmic Origins Spectrograph.
Charles R. Proffitt, Harim Jin, Simone Daflon, Daniel J. Lennon, Norbert Langer, Katia Cunha, Talawanda Monroe   +6 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A High-resolution Spectroscopic Survey of Directly Imaged Companion Hosts. II. Diversity in C/O Ratios among Host Stars

The Astronomical Journal
The era of JWST has enabled measurements of abundances of elements such as C, O, and even Na, S, K, and Fe in planetary atmospheres to very high precisions (∼0.1 dex).
Aneesh Baburaj, Quinn M. Konopacky, Christopher A. Theissen, Roman Gerasimov, Kielan K. W. Hoch   +4 more
doaj   +1 more source

Higher depletion of lithium in planet host stars: no age and mass effect

, 2010
Recent observational work by Israelian et al. has shown that sun-like planet host stars in the temperature range 5700K < Teff < 5850K have lithium abundances that are significantly lower than those observed for "single" field stars. In this letter we use
Castro, Charbonnel, Chen, Chen, Claret, Cochran, Deliyannis, Dziembowski, Ecuvillon, Eggleton, Favata, Fernandes, Fischer, G. Israelian, Galeev, Garcia Lopez, Gilli, Gonzalez, Gonzalez, Israelian, Israelian, Israelian, J. Fernandes, King, Lambert, Lastennet, Luck, Mayor, Mordasini, Morel, N. C. Santos, Neves, Pasquini, Pinsonneault, Pollack, Randich, Randich, Ryan, S. G. Sousa, Santos, Santos, Santos, Santos, Sestito, Sousa, Takeda, Takeda, Udry, Valenti   +48 more
core   +1 more source

Stellar Population Models and Individual Element Abundances. I. Sensitivity of Stellar Evolution Models [PDF]

, 2007
Aaron Dotter, Brian Chaboyer, Jason W. Ferguson, Hyun‐Chul Lee, Guy Worthey, Darko Jevremović, E. Baron   +6 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source