Results 171 to 180 of about 895,436 (365)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Observations of the Ultraviolet-bright Star III-60 in the Globular Cluster NGC 6723
The Astrophysical JournalWe have analyzed archival far-ultraviolet spectra of the UV-bright star III-60 in the globular cluster NGC 6723 obtained with the Far Ultraviolet Spectroscopic Explorer and the Cosmic Origins Spectrograph. We find that the star's photospheric parameters (
William V. Dixon
doaj +1 more source
The Galactic Disk-Halo Transition – Evidence from Stellar Abundances [PDF]
, 2008 P. E. Nissen, W. J. Schuster
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The Impact of Stellar Rotation on the Nitrogen Abundance Gradient from OB Stars in the Galactic Disk [PDF]
, 2004 S. Daflon, Kátia Cunha
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Astrophysical JournalStellar abundance measurements are subject to systematic errors that induce extra scatter and artificial correlations in elemental abundance patterns. We derive empirical calibration offsets to remove systematic trends with surface gravity $\mathrm{log ...
Tawny Sit +6 more
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Stellar Evolutionary Effects on the Abundances of Polycyclic Aromatic Hydrocarbons and Supernova‐Condensed Dust in Galaxies [PDF]
, 2008 Frederic Galliano +2 more
openalex +1 more source