Results 181 to 190 of about 895,436 (365)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Abundance Measurements of the Metal-poor M Subdwarf LHS 174 Using High-resolution Optical Spectroscopy

The Astronomical Journal
Metal-poor M subdwarfs are among the oldest stellar populations and carry valuable information about the chemical enrichment history of the Milky Way. The measurements of chemical abundances of these stars therefore provide essential insights into the ...
Neda Hejazi, Sébastien Lépine, Thomas Nordlander, Wei-Chun Jao, David R. Coria, Kathryn V. Lester   +5 more
doaj   +1 more source

Observable Effects of Rotation on Stellar Abundances [PDF]

, 1993
S. Balachandran
openalex   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Atomic Data for Astrophysically Important Spectral Lines of Singly Ionized Nitrogen

The Astrophysical Journal
Nitrogen lines are widely observed in astrophysical spectra and provide important diagnostics for plasma properties. In this work, we present extended calculations for accurate energy levels, electric dipole radiative transition parameters, and lifetimes
M. C. Li, W. Li
doaj   +1 more source

Stellar abundance analyses in the light of 3D hydrodynamical model\n atmospheres [PDF]

, 2003
M. Asplund
openalex   +1 more source

Predictions for complex distributions of stellar elemental abundances in low-mass galaxies [PDF]

, 2022
P. Patel, Sarah Loebman, Andrew Wetzel, Claude‐André Faucher‐Giguère, Kareem El-Badry, Jeremy Bailin   +5 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

A Data-driven Spectral Model of Main-sequence Stars in Gaia DR3

The Astrophysical Journal
Precise spectroscopic classification of planet hosts is an important tool of exoplanet research at both the population and individual system level.
Isabel Angelo, Megan Bedell, Erik Petigura, Melissa Ness   +3 more
doaj   +1 more source