Results 191 to 200 of about 895,436 (365)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The Astrophysical JournalReliable estimation of stellar surface gravity (log g ) for a large sample is crucial for evaluating stellar evolution models and understanding galactic structure; however, it is not easy to accomplish due to the difficulty in gathering a large ...
Qiqian Zhang +18 more
doaj +1 more source
Chemical abundances in metal-poor giants: limitations imposed by the use of classical 1D stellar atmosphere models [PDF]
, 2011 V. Dobrovolskas +5 more
openalex +1 more source
Detailed Abundances in the Galactic Center: Evidence of a Metal-rich Alpha-enhanced Stellar Population [PDF]
, 2020 B. Thorsbro +10 more
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Iron Snails: Nonequilibrium Dynamics and Spiral Abundance Patterns
The Astrophysical JournalGalaxies are not in a dynamical steady state: they continually undergo perturbations, e.g., from infalling dwarf galaxies and dark matter substructure. After a dynamical perturbation, stars phase mix toward a new steady state; in so doing, they generally
Neige Frankel +4 more
doaj +1 more source
Measuring Ages and Elemental Abundances from Unresolved Stellar Populations: Fe, Mg, C, N, and Ca [PDF]
, 2008 Genevieve J. Graves, Ricardo P. Schiavon
openalex +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Chemical Abundances in the Leiptr Stellar Stream: A Disrupted Ultra-faint Dwarf Galaxy?
The Open Journal of AstrophysicsChemical abundances of stellar streams can be used to determine the nature of a stream's progenitor. Here we study the progenitor of the recently discovered Leiptr stellar stream, which was previously suggested to be a tidally disrupted halo globular ...
Kaia R. Atzberger +13 more
doaj +1 more source