Results 211 to 220 of about 895,436 (365)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Stellar Compositions from Narrow-Band Photometry -- III: Iron Abundances in a Further 120 Evolved Stars [PDF]
, 1972 P. M. Williams
openalex +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Investigating Non-LTE Abundances of Neodymium in Metal-poor FGK Stars
The Astrophysical JournalThe dominant site(s) of the r -process are a subject of current debate. Ejecta from r -process-enrichment events like kilonovae are difficult to directly measure, so we must instead probe abundances in metal-poor stars to constrain r -process models ...
John D. Dixon +5 more
doaj +1 more source
Stellar parameters and abundances [PDF]
Proceedings of 11th Symposium on Nuclei in the Cosmos — PoS(NIC XI), 2011 openaire +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Inferring Stellar Parameters from Iodine-imprinted Keck/HIRES Spectra with Machine Learning
The Astrophysical Journal LettersThe properties of exoplanet host stars are traditionally characterized through a detailed forward-modeling analysis of high-resolution spectra. However, many exoplanet radial velocity surveys employ iodine-cell-calibrated spectrographs, such that the ...
Jude Gussman, Malena Rice
doaj +1 more source
Stellar Abundances In The Solar Neighborhood
, 2012 The only elements that were made in significant quantity during the Big Bang were hydrogen and helium, and to a lesser extent lithium. Depending on the initial mass of a star, it may eject some or all of the unique, newly formed elements into the interstellar medium.
openaire +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
The Helium Abundance of NGC 6791 from Modeling of Stellar Oscillations [PDF]
, 2019 Jean M. McKeever +2 more
openalex +1 more source