Results 41 to 50 of about 942 (213)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Signatures of Stellar Accretion in MaNGA Early-type Galaxies [PDF]

The Astrophysical Journal, 2019
Abstract The late assembly of massive galaxies is thought to be dominated by stellar accretion in their outskirts (beyond two effective radii R e) due to dry, minor galaxy mergers. We use observations of 1010 passive early-type galaxies (ETGs) within z < 0.15 from MaNGA (Mapping Nearby Galaxies at Apache Point ...
Grecco A. Oyarzún, Kevin Bundy, Kyle B. Westfall, Francesco Belfiore, Daniel Thomas, Claudia Maraston, Jianhui Lian, Alfonso Aragón-Salamanca, Zheng Zheng, Violeta Gonzalez-Perez, David R. Law, Niv Drory, Brett H. Andrews   +12 more
openaire   +5 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Magnetospheric Accretion and PMS Stellar Masses

, 1998
Accepted by MNRAS.
Bonnell, Ian A., Smith, Kester W., Meyer, Michael R., Tout, Christopher A., Folha, Daniel F. M., Emerson, James P.   +5 more
openaire   +2 more sources

Outflows and Accretion in Young Stellar Objects [PDF]

Symposium - International Astronomical Union, 2004
Outflows in young stellar objects are powered by accretion, and ∼ 0.1 of the accreted material is lost in the outflow. Observational evidence is analyzed in the context of models for the origin of the wind. Winds in FU Ori objects are clear examples of disk winds.
openaire   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Neutron star accretion in a stellar envelope

The Astrophysical Journal, 1993
Steady spherically symmetric accretion onto a neutron star is possible for a mass accretion rate ˙M≥10 −3 M ○. yr −1 ; the gravitational energy is lost to neutrinos. In the scenario of neutron star spiral-in through a massive stellar envelope, the neutron star accretion rate derived from the Bondi-Hoyle theory is ≥0.2 M ○. yr −1 . Radiation pressure
openaire   +1 more source