Results 241 to 250 of about 8,281,459 (308)

Stellar rotation in the intermediate-age massive cluster NGC 1783: clues on the nature of UV-dim stars [PDF]

Silvia Leanza, E. Dalessandro, Mario Cadelano, C. Fanelli, Greta Ettorre, Sebastian Kamann, N. Bastian, S. Martocchia, Maurizio Salaris, C. Lardo, A. Mucciarelli, Sara Saracino   +11 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A binary system in the S cluster close to the supermassive black hole Sagittarius A. [PDF]

Nat Commun
Peißker F, Zajaček M, Labadie L, Bordier E, Eckart A, Melamed M, Karas V.   +6 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A high-velocity star recently ejected by an intermediate-mass black hole in M15. [PDF]

Natl Sci Rev
Huang Y, Li Q, Liu J, Dong X, Zhang H, Lu Y, Du C.   +6 more
europepmc   +1 more source

Revealing the chemical structure of the Magellanic Clouds with APOGEE. I. Calculating individual stellar ages of RGB stars in the Large Magellanic Cloud

Joshua Povick, David L. Nidever, Pol Massana, Jamie Tayar, Knut Olsen, Sten Hasselquist, Maria-Rosa L. Cioni, Christian Nıtschelm, R. Carrera, Yumi Choi, Alexandre Roman–Lopes, Steven R. Majewski, Andrés Almeida, Kátia Cunha, Verne V. Smith   +14 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Terrestrial atmospheric ion implantation occurred in the nearside lunar regolith during the history of Earth's dynamo. [PDF]

Commun Earth Environ
Paramanick S, Blackman EG, Tarduno JA, Carroll-Nellenback J.   +3 more
europepmc   +1 more source

A link between rocky planet composition and stellar age

Angharad Weeks, Vincent Van Eylen, Daniel Huber, Daisuke Kawata, Amalie Stokholm, V. Silva Aguirre, Paola Pinilla, Jakob Rørsted Mosumgaard, Mark Lykke Winther, Travis A. Berger   +9 more
openalex   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source