Results 241 to 250 of about 7,481 (302)

A luminous and young galaxy at z = 12.33 revealed by a JWST/MIRI detection of Hα and [O iii]. [PDF]

Nat Astron
Zavala JA, Castellano M, Akins HB, Bakx TJLC, Burgarella D, Casey CM, Chávez Ortiz ÓA, Dickinson M, Finkelstein SL, Mitsuhashi I, Nakajima K, Pérez-González PG, Arrabal Haro P, Bergamini P, Buat V, Backhaus B, Calabrò A, Cleri NJ, Fernández-Arenas D, Fontana A, Franco M, Grillo C, Giavalisco M, Grogin NA, Hathi N, Hirschmann M, Ikeda R, Jung I, Kartaltepe JS, Koekemoer AM, Larson RL, McKinney J, Papovich C, Rosati P, Saito T, Santini P, Terlevich R, Terlevich E, Treu T, Yung LYA.   +39 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Using JADES NIRCam photometry to investigate the dependence of stellar mass inferences on the IMF in the early universe. [PDF]

Proc Natl Acad Sci U S A
Woodrum C, Rieke M, Ji Z, Baker WM, Bhatawdekar R, Bunker AJ, Charlot S, Curtis-Lake E, Eisenstein DJ, Hainline K, Hausen R, Helton JM, Hviding RE, Johnson BD, Robertson B, Sun F, Tacchella S, Whitler L, Williams CC, Willmer CNA.   +19 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Models and observational predictions of dust traps in protoplanetary discs. [PDF]

Astrophys Space Sci
Pinilla P.
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Childhood and contemporaneous inflammation in depersonalisation and derealisation: Longitudinal evidence from the Avon Longitudinal Study of Parents and Children. [PDF]

Brain Behav Immun Health
Dilkes E, Gillmeister H, Daughters K.
europepmc   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Using reciprocally retained gene families to detect whole-genome multiplications in plants. [PDF]

Genome Biol
Tasdighian S, Sensalari C, Maere S.
europepmc   +1 more source