Results 61 to 70 of about 95,404 (302)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

AME - Asteroseismology Made Easy. Estimating stellar properties by use of scaled models [PDF]

, 2014
We present a new method to obtain stellar properties for stars exhibiting solar-like oscillations in an easy, fast, and transparent way. The method, called Asteroseismology Made Easy (AME), can determine stellar masses, mean-densities, radii, and surface
Aguirre, V. Silva, Kjeldsen, H., Lundkvist, M.   +2 more
core   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

The APO-K2 Catalog. II. Accurate Stellar Ages for Red Giant Branch Stars across the Milky Way

The Astronomical Journal
We present stellar age determinations for 4661 red giant branch stars in the APO-K2 catalog, derived using mass estimates from K2 asteroseismology from the K2 Galactic Archaeology Program and elemental abundances from the Apache Point Galactic Evolution ...
Jack T. Warfield, Joel C. Zinn, Jessica Schonhut-Stasik, James W. Johnson, Marc H. Pinsonneault, Jennifer A. Johnson, Dennis Stello, Rachael L. Beaton, Yvonne Elsworth, Rafael A. García, Savita Mathur, Benoît Mosser, Aldo Serenelli, Jamie Tayar   +13 more
doaj   +1 more source

Fundamentals of stellar evolution and nucleosynthesis [PDF]

EPJ Web of Conferences
The theory of stellar structure and evolution plays a pivotal role in modern astrophysics. Stellar evolution calculations are used to determine the ages and, to a lesser extent, distances of stars, which are critical to our knowledge of the history and ...
Vescovi Diego
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

APOKASC-3: The Third Joint Spectroscopic and Asteroseismic Catalog for Evolved Stars in the Kepler Fields

The Astrophysical Journal Supplement Series
In the third APOKASC catalog, we present data for the complete sample of 15,808 evolved stars with APOGEE spectroscopic parameters and Kepler asteroseismology.
Marc H. Pinsonneault, Joel C. Zinn, Jamie Tayar, Aldo Serenelli, Rafael A. García, Savita Mathur, Mathieu Vrard, Yvonne P. Elsworth, Benoit Mosser, Dennis Stello, Keaton J. Bell, Lisa Bugnet, Enrico Corsaro, Patrick Gaulme, Saskia Hekker, Marc Hon, Daniel Huber, Thomas Kallinger, Kaili Cao, Jennifer A. Johnson, Bastien Liagre, Rachel A. Patton, Ângela R. G. Santos, Sarbani Basu, Paul G. Beck, Timothy C. Beers, William J. Chaplin, Katia Cunha, Peter M. Frinchaboy, Léo Girardi, Diego Godoy-Rivera, Jon A. Holtzman, Henrik Jönsson, Szabolcs Mészáros, Claudia Reyes, Hans-Walter Rix, Matthew Shetrone, Verne V. Smith, Taylor Spoo, Keivan G. Stassun, Ji Wang   +40 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Constraining the metallicities, ages, star formation histories, and ionizing continua of extragalactic massive star populations

, 2019
We infer the properties of massive star populations using the far-ultraviolet stellar continua of 61 star-forming galaxies: 42 at low-z observed with HST and 19 at z~2 from the Megasaura sample.
Bayliss, M., Berg, D. A., Chisholm, J., Dahle, H., Gladders, M., Rigby, J. R., Sharon, K.   +6 more
core   +1 more source