Results 191 to 200 of about 71,994 (275)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Expanding Targeted Instrumentation for Discovery Applications: Complement Reporter Ion Quantification with a Quadrupole-Ion Trap Instrument. [PDF]

J Proteome Res
Cruz ER, Johnson ANT, Pujari V, Zhang Q, Nguyen T, Stadlmeier M, Wang J, Jacob CC, McAlister GC, Remes PM, Wühr M.   +10 more
europepmc   +1 more source

The Classification of Stellar Spectra

The Astrophysical Journal, 1935
N. Russell, Cecilia H. Payne Gaposchkin, D. H. Menzel   +2 more
openaire   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Little red dots as young supermassive black holes in dense ionized cocoons. [PDF]

Nature
Rusakov V, Watson D, Nikopoulos GP, Brammer G, Gottumukkala R, Harvey T, Heintz KE, Damgaard R, Sim SA, Sneppen A, Vijayan AP, Adams N, Austin D, Conselice CJ, Goolsby CM, Toft S, Witstok J.   +16 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Stellar classification from simulated DIVA spectra. I. Solar metallicity stars

Open Astronomy, 1999
Elsner B., Bastian U., Liubertas R., Scholz R.   +3 more
doaj   +1 more source

Sotatercept in Pulmonary Arterial Hypertension: Molecular Mechanisms, Clinical Evidence, and Emerging Role in Reverse Remodelling. [PDF]

Int J Mol Sci
Tilea I, Iancu DG, Fira-Mladinescu O, Bertici N, Varga A.   +4 more
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Use of Sotatercept to Facilitate Transition From Intravenous to Oral Prostacyclin Therapy. [PDF]

Clin Respir J
Dagher C, Akiki M, Swanson K, Carollo B, Chernobelsky E, Farber HW, Parikh R.   +6 more
europepmc   +1 more source