Results 51 to 60 of about 64,602 (241)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
FEBS Letters, EarlyView.Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard +7 more
wiley +1 more source
A Data-driven Spectral Model of Main-sequence Stars in Gaia DR3
The Astrophysical JournalPrecise spectroscopic classification of planet hosts is an important tool of exoplanet research at both the population and individual system level.
Isabel Angelo +3 more
doaj +1 more source
FEBS Letters, EarlyView.We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti +2 more
wiley +1 more source
Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions
FEBS Letters, EarlyView.This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten +10 more
wiley +1 more source
Classification of Stars from Redshifted Stellar Spectra utilizing Machine Learning [PDF]
, 2019 The classification of stellar spectra is a fundamental task in stellar astrophysics. There have been many explorations into the automated classification of stellar spectra but few that involve the Sloan Digital Sky Survey (SDSS). Stellar spectra from the
Brice, Michael J.
core +1 more source
Observational evidence for the origin of X-ray sources in globular clusters [PDF]
, 2007 Low-mass X-ray binaries, recycled pulsars, cataclysmic variables and magnetically active binaries are observed as X-ray sources in globular clusters. We discuss the classification of these systems, and find that some presumed active binaries are brighter
Cees Bassa +11 more
core +2 more sources
S-PLUS: LEnticular Galaxies in Stripe 82 (LEGS82) [PDF]
Anais da Academia Brasileira de CiênciasThis work is a Brazilian-Indian collaboration. It aims at investigating the structural properties of Lenticular galaxies in the Stripe 82 using a combination of S-PLUS (Southern Photometric Local Universe Survey) and SDSS data.
ARIANNA CORTESI +7 more
doaj +2 more sources
An Evenly Spaced LSST Cadence for Rapidly Variable Stars
The Astrophysical Journal Supplement Series, 2023 Stars exhibit a bewildering variety of rapidly variable behaviors ranging from explosive magnetic flares to stochastically changing accretion to periodic pulsations or rotation.
Eric D. Feigelson +2 more
doaj +1 more source
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source