Results 231 to 240 of about 41,445 (309)

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

A hybrid stellar mass black-hole optimization framework for finding significant biclusters using average Kendall rank correlation. [PDF]

Sci Rep
Balamurugan R.
europepmc   +1 more source

Wide‐Range Adaptive Metal Oxide for Hydrogen Sulfide Detection From Earth to Space‐Like Environments

Advanced Science, EarlyView.
This work presents a gas sensing platform based on Cu‐doped SnO2 microspheres that operates reliably from ambient to space‐like conditions. The sensor maintains performance across vacuum and cryogenic environments, bypassing traditional oxygen‐mediated mechanisms, utilizing direct chemisorption and interfacial charge transfer.
Xi Chen, Jiaxin Chen, Yanghui Liu, Junhao Cao, Yang Yuan, Kaixin Chen, Yilang Ye, Tongshuai Yang, Yongqing Fu, Wei Luo   +9 more
wiley   +1 more source

NASA'S <i>Lucy</i> Mission to Trojan Asteroids: Unraveling the History of the Outer Solar System. [PDF]

Space Sci Rev
Levison HF, Marchi S, Noll KS, Spencer JR, Olkin CB, Statler TS.   +5 more
europepmc   +1 more source

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

Advanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He, Anqi Zhang, Zhanchen Guo, Qi Li, Song Gao, Wenyan Guan, Ying Li, Jingran Chen, Sijia Sun, Jian He, Zhen Liu   +10 more
wiley   +1 more source

Mapping the nonribosomal specificity code through promiscuity-guided A-domain engineering. [PDF]

Chem Sci
Stanišić A, Svensson CM, Müll M, Bernal FA, Zeihe H, Ettelt U, Kries H.   +6 more
europepmc   +1 more source

SR‐B1‐Mediated Transplacental Transfer of Hydrophobic Toxicants Disrupts Fetal Development During Barriergenesis

Advanced Science, EarlyView.
This study maps the spatiotemporal distribution of hydrophobic toxicants and endogenous metabolites in the developing placenta and fetus. By integrating mass spectrometry imaging with snRNA‐seq, we identify SR‐B1 as a key transporter driving early‐gestation xenobiotic transfer and reveal a critical exposure window associated with persistent fetal ...
Yixuan Huang, Hailin Shang, Ling Jiao, Ce Chen, Zehua Liu, Yi Yang, Qiannan Zhang, Song Tang, Xudong Jia, Hui Yang, Yi Wan   +10 more
wiley   +1 more source

A pilot study of maternal vitamin D status and its association with breast milk and infant gut metabolites. [PDF]

Physiol Rep
Gutierrez AS, Chetta KE, Thapa S, Haidacher SJ, Hoch KM, Baatz JE, Haag AM, Oezguen N, Horvath TD, Wagner CL, Engevik MA.   +10 more
europepmc   +1 more source

Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound

Advanced Science, EarlyView.
In this study, Qiu et al. found that low‐intensity ultrasound can directly activate sparse ultrasound‐sensitive neurons (UNs) in the primary visual cortex (V1) of deafened mice. The proportion of these sparse UNs is pressure‐dependent. Furthermore, ultrasound modulates visual circuitry with distinct excitatory and inhibitory effects.
Jiaru He, Jiejun Zhu, Xinxin Wang, Zihao Chen, Jin Yang, Zhen Yuan, Hongzhi Xu, Lei Sun, Zhihai Qiu   +8 more
wiley   +1 more source

Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High-Throughput PRM-MS in an Inflammatory Bowel Disease Cohort. [PDF]

Angew Chem Int Ed Engl
Fu Q, Remes PM, Lee J, Jacob C, Li D, Vegesna M, Raedschelders K, Haghani A, Mengesha E, Debbas P, Hoedt E, Joung S, Cheng S, Peterman S, Fert-Bober J, Melmed GY, McGovern DPB, Murray CI, Van Eyk JE.   +18 more
europepmc   +1 more source