Results 241 to 250 of about 41,445 (309)

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

Calcium in a supernova remnant as a fingerprint of a sub-Chandrasekhar-mass explosion. [PDF]

Nat Astron
Das P, Seitenzahl IR, Ruiter AJ, Röpke FK, Pakmor R, Vogt FPA, Collins CE, Ghavamian P, Sim SA, Williams BJ, Taubenberger S, Laming JM, Suherli J, Sutherland R, Rodríguez-Segovia N.   +14 more
europepmc   +1 more source

Integral Field Spectroscopy of Collisional Ring Galaxies I: Stellar Populations Analysis [PDF]

M. Chow-Martínez, A. C. Robleto-Orús, Y D Mayya, J P Torres-Papaqui, R A Ortega-Minakata, D F Castro-Hidalgo, C A Caretta, J J Trejo-Alonso, A. Morales-Vargas, R García-Benito, H E Jácamo-Delgado, Marco A. Gudino   +11 more
openalex   +1 more source

A Quest for the Mechanism of Ultrahigh Resolution SEM Imaging

Advanced Science, EarlyView.
Using Monte Carlo simulations with explicit definitions of SE1 and SE2 align with a cascade secondary electron production model, this work shows that the 3D nanostructure modulated SE2 emission enhances other than to reduce topographical contrast via a “miniature Faraday cup” effect.
Hao Tian Chen, Y.B. Zou, B. Da, Z.J. Ding   +3 more
wiley   +1 more source

Laser-based approach to measure small nuclear cross sections in plasma. [PDF]

Proc Natl Acad Sci U S A
Feng J, Qi J, Zhang H, Chen S, Zhu M, Hu X, Xu H, Fu C, Wang X, Chen L, Zhang J.   +10 more
europepmc   +1 more source

TOGR3, a Proteasome β4 Subunit, Orchestrates Sugar Homeostasis to Trade Off Growth and Thermotolerance in Rice

Advanced Science, EarlyView.
This study identifies a novel thermoregulatory mechanism in rice: TOGR3 partners with 26S proteasome subunits, including TT1, to drive thermoresponsive ubiquitin–proteasome activity, maintaining sugar homeostasis in stomatal regulation to balance growth and stress resistance.
Biyao Zhang, Xiaoyan Wu, Ting Xu, Feifei Guo, Xiaolu Shen, Cuiping Meng, Yanan Wang, Xue Han, Hong Zhao, Yongbiao Xue   +9 more
wiley   +1 more source

Simplified Analysis of Native Steroid Esters in Dried Blood Spots by LC-MS³. [PDF]

J Mass Spectrom
Thomas A, Thelen J, Sakellariou P, Thevis M.   +3 more
europepmc   +1 more source

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, EarlyView.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source

Terrestrial atmospheric ion implantation occurred in the nearside lunar regolith during the history of Earth's dynamo. [PDF]

Commun Earth Environ
Paramanick S, Blackman EG, Tarduno JA, Carroll-Nellenback J.   +3 more
europepmc   +1 more source