Results 151 to 160 of about 1,362,486 (349)
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The Astrophysical JournalWith new atomic-hydrogen (H i ) observations of FAST Extended Atlas of Selected Targets Survey (FEASTS), we present the first statistical comparison of H i morphology between observations and cosmological simulations, focusing on low-column-density (∼10 ^
Xuchen Lin +4 more
doaj +1 more source
The Role of Stellar Feedback in Galaxy Evolution
, 2009 Aiming at understanding the role of stellar feedback in galaxy evolution, I present a study of the hot interstellar medium in several representative galaxies, based primarily on X-ray observations as well as theoretical modelling. I find that, in the massive disk galaxies NGC2613 and M104, the observed amount of hot gas is much less than that ...
openaire +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Testable Predictions of Outside-in Age Gradients in Dwarf Galaxies of All Types
The Astrophysical JournalWe use a sample of 73 simulated satellite and central dwarf galaxies spanning a stellar mass range of 10 ^5.3 –10 ^9.1 M _⊙ to investigate the origin of their stellar age gradients.
Claire L. Riggs +6 more
doaj +1 more source
SYGMA: Stellar Yields for Galactic Modeling Applications
, 2018 The stellar yields for galactic modeling applications (SYGMA) code is an open-source module that models the chemical ejecta and feedback of simple stellar populations (SSPs).
Côté, Benoit +4 more
core +1 more source
SUSTAINING GALAXY EVOLUTION: THE ROLE OF STELLAR FEEDBACK
Publications of The Korean Astronomical Society, 2015 We have conducted a near-infrared monitoring campaign at the UK InfraRed Telescope (UKIRT), of the Local Group galaxy M33. The main aim was to identify stars in the very final stage of their evolution, and for which the luminosity is more directly related to the birth mass than the more numerous less-evolved giant stars that continue to increase in ...
ATEFEH JAVADI +2 more
openaire +2 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
The Astrophysical JournalObservations indicate that early-type galaxies exhibit varying slopes in the relation between their central stellar surface density and stellar mass (Σ _1 – M _⋆ ).
Fazeel Mahmood Khan +4 more
doaj +1 more source