The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda+9 more
wiley +1 more source
Tidal tail identification and detailed analysis of the open star cluster King 13 using Gaia DR3 and 2MASS. [PDF]
Ahmed NM, Darwish MS.
europepmc +1 more source
Nitric oxide‐forming nitrite reductases in the anaerobic ammonium oxidizer Kuenenia stuttgartiensis
Anammox bacteria remove fixed nitrogen from their environment via anaerobic ammonium oxidation (anammox) with nitrite as electron acceptor and dinitrogen gas as product. The first anammox step is the conversion of nitrite to nitric oxide by nitrite reductase.
Femke J. Vermeir+4 more
wiley +1 more source
Evidence of star cluster migration and merger in dwarf galaxies. [PDF]
Poulain M+10 more
europepmc +1 more source
Ages, Distances, and the Initial Mass Functions of Stellar Clusters
J. R. Stauffer+3 more
openalex +2 more sources
Orbital Perturbations of Transiting Planets: A Possible Method to Measure Stellar Quadrupoles and to Detect Earth‐Mass Planets [PDF]
Jordi Miralda‐Escudé
openalex +1 more source
Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu+12 more
wiley +1 more source
Acoustic modes in M67 cluster stars trace deepening convective envelopes. [PDF]
Reyes C+5 more
europepmc +1 more source
Gravitational Microlensing Events Due to Stellar‐Mass Black Holes [PDF]
D. P. Bennett+30 more
openalex +1 more source