Results 251 to 260 of about 3,795,687 (315)

A giant disk galaxy two billion years after the Big Bang. [PDF]

Nat Astron
Wang W, Cantalupo S, Pensabene A, Galbiati M, Travascio A, Steidel CC, Maseda MV, Pezzulli G, de Beer S, Fossati M, Fumagalli M, Gallego SG, Lazeyras T, Mackenzie R, Matthee J, Nanayakkara T, Quadri G.   +16 more
europepmc   +1 more source

Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam, Ali Laith, Aslihan Gunel, Melda Yilmaz, Nazli Basak, Halil Idrisoglu, P. Hande Ozdinler   +6 more
wiley   +1 more source

A transiting giant planet in orbit around a 0.2-solar-mass host star. [PDF]

Nat Astron
Bryant EM, Jordán A, Hartman JD, Bayliss D, Sedaghati E, Barkaoui K, Chouqar J, Pozuelos FJ, Thorngren DP, Timmermans M, Almenara JM, Chilingarian IV, Collins KA, Gan T, Howell SB, Narita N, Palle E, Rackham BV, Triaud AHMJ, Bakos GÁ, Brahm R, Hobson MJ, Van Eylen V, Amado PJ, Arnold L, Bonfils X, Burdanov A, Cadieux C, Caldwell DA, Casanova V, Charbonneau D, Clark CA, Collins KI, Daylan T, Dransfield G, Demory BO, Ducrot E, Fernández-Rodríguez G, Fukuda I, Fukui A, Gillon M, Gore R, Hooton MJ, Ikuta K, Jehin E, Jenkins JM, Levine AM, Littlefield C, Murgas F, Nguyen K, Parviainen H, Queloz D, Seager S, Sebastian D, Srdoc G, Vanderspek R, Winn JN, de Wit J, Zúñiga-Fernández S.   +58 more
europepmc   +1 more source

Development of highly multiplex targeted proteomics assays in biofluids using the Stellar mass spectrometer

Deanna L. Plubell, Philip M. Remes, Christine C. Wu, Cristina C. Jacob, Gennifer E. Merrihew, Chris Hsu, Nick Shulman, Brendan MacLean, Lilian R. Heil, Kathleen L. Poston, Tom Montine, Michael J. MacCoss   +11 more
openalex   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

Photometric detection at 7.7 μm of a galaxy beyond redshift 14 with JWST/MIRI. [PDF]

Nat Astron
Helton JM, Rieke GH, Alberts S, Wu Z, Eisenstein DJ, Hainline KN, Carniani S, Ji Z, Baker WM, Bhatawdekar R, Bunker AJ, Cargile PA, Charlot S, Chevallard J, D'Eugenio F, Egami E, Johnson BD, Jones GC, Lyu J, Maiolino R, Pérez-González PG, Rieke MJ, Robertson B, Saxena A, Scholtz J, Shivaei I, Sun F, Tacchella S, Whitler L, Williams CC, Willmer CNA, Willott C, Witstok J, Zhu Y.   +33 more
europepmc   +1 more source

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

Measuring the magnetic fields in the chromospheres of low-mass stars

Cang T, Petit P, Donati J, Tian H, Fu J, Li H, Bellotti S, Hu X, Ma X, Ariste AL, Xing K, Morin J, Lu H, Zong W.   +13 more
europepmc   +1 more source

Stellar structure via truncated M-fractional Lane-Emden solutions. [PDF]

Sci Rep
Nouh MI, Abdel-Salam EA, Hassaballa AA, Awad AM, Jazmati MS, Bahgat MSM.   +5 more
europepmc   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source