Results 91 to 100 of about 165,855 (235)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Biases and Uncertainties in Physical Parameter Estimates of Lyman Break Galaxies from Broad-band Photometry

open access: yes, 2008
We investigate the biases and uncertainties in estimates of physical parameters of high-redshift Lyman break galaxies (LBGs), such as stellar mass, mean stellar population age, and star formation rate (SFR), obtained from broad-band photometry.
Adelberger   +44 more
core   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Probing Populations of Dark Stellar Remnants in the Globular Clusters 47 Tuc and Terzan 5 Using Pulsar Timing

open access: yesThe Astrophysical Journal
We present a new method to combine multimass equilibrium dynamical models and pulsar timing data to constrain the mass distribution and remnant populations of Milky Way globular clusters (GCs).
Peter J. Smith   +4 more
doaj   +1 more source

Evolution of the Most Massive Galaxies to z=0.6: I. A New Method for Physical Parameter Estimation

open access: yes, 2011
We use principal component analysis (PCA) to estimate stellar masses, mean stellar ages, star formation histories (SFHs), dust extinctions and stellar velocity dispersions for ~290,000 galaxies with stellar masses greater than $10^{11}Msun and redshifts ...
Abazajian   +123 more
core   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

Disentangling age and metallicity in distant unresolved stellar systems

open access: yes, 2008
We present some results of an observational and theoretical study on unresolved stellar systems based on the Surface Brightness Fluctuations (SBF) technique.
Amedeo Tornambe   +9 more
core   +1 more source

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