Results 131 to 140 of about 12,166 (296)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Resolved Stellar Mass Estimation of Nearby Late-type Galaxies for the SPHEREx Era: Dependence on Stellar Population Synthesis Models

The Astronomical Journal
The upcoming all-sky infrared spectrophotometric SPHEREx mission is set to provide spatially resolved stellar mass maps of nearby galaxies, offering more detailed insights than integrated light observations.
Jeong Hwan Lee, Minjin Kim, Taehyun Kim, Hyunjin Shim, Luis C. Ho, Ho Seong Hwang, Hyunmi Song, Dohyeong Kim, Yujin Yang, Woong-Seob Jeong   +9 more
doaj   +1 more source

Chandra Observations of the Stellar Populations and Diffuse Gas in Nearby Galaxies [PDF]

, 2001
A. Zezas, G. Fabbiano, Andrea Prestwich, M. J. Ward, S. S. Murray   +4 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The Pleiades Binary Fraction Revisited

The Astronomical Journal
One of the nearest and best-studied open clusters, the Pleiades is an important cornerstone of stellar astrophysics. Despite its role as a reference coeval stellar population, its multiplicity properties are still not well characterized. The combined use
Dmitry Chulkov
doaj   +1 more source

Planetary nebulae as tracers of stellar population properties: a pilot study with MUSE [PDF]

Ana Inés Ennis, Johanna Hartke, Fuyan Bian, C. Pulsoni, Chiara Spiniello, M. Arnaboldi, R. De Pietri   +6 more
openalex   +1 more source

Chemical fingerprinting of stellar populations in the Milky Way halo [PDF]

, 2012
Mei-Yin Chou
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Higher-order Balmer line indices inα/Fe-enhanced stellar population models [PDF]

, 2004
D. Thomas, Claudia Maraston, A. J. Korn
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source