Results 131 to 140 of about 5,213,633 (303)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Final report on the STELLAR Delphi study: Future directions for TEL and TEL research: areas of tension, core research areas and grand challenge problems

, 2012
In this report on the STELLAR Delphi study, we present the results of the final global survey, that is the 4th STELLAR Delphi round, and illustrate the elaboration and dissemination of these results (5th STELLAR Delphi round).
Spada, Hans, Plesch, Christine, Wiedmann, Michael   +2 more
core  

New Zealand regions, 1986-2001: Population dynamics [PDF]

, 2005
New Zealand regions have markedly different population dynamics. Population change in a region is driven by three different factors: fertility, mortality and migration.
Lindop, J., Pool, Ian, Baxendine, Sandra, Cochrane, William   +3 more
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The Origin of Young Stellar Populations in NGC 1783: Accretion of External Stars

The Astrophysical Journal
The presence of young stellar populations in the Large Magellanic Cloud cluster NGC 1783 has caught significant attention, with suggestions ranging from it being a genuine secondary stellar generation to a population of blue straggler stars or simply ...
Li Wang, Licai Deng, Xiaoying Pang, Long Wang, Richard de Grijs, Antonino P. Milone, Chengyuan Li   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Unveiling the Cygnus OB2 stellar population with Chandra

, 2006
Aims.The aim of this work is to identify the so far unknown low mass stellar population of the ~2 Myr old Cygnus OB2  star forming region, and to investigate the X-ray and near-IR stellar properties of its members. Methods.We analyzed a 97.7 ks
S. Sciortino, E. Flaccomio, J. F. Albacete Colombo, F. Damiani, G. Micela   +4 more
core   +1 more source

Dynamical Cluster Assembly Framework (D-CAF): The Link between Star Cluster Formation and Expansion Rates

The Astrophysical Journal
We introduce the Dynamical Cluster Assembly Framework (D-CAF), an AMUSE-based framework designed to connect embedded star formation histories to the dynamical evolution of young stellar systems.
Juan P. Farias, Alison Sills
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source