Results 191 to 200 of about 6,178,117 (397)

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

The Impact of Local Stellar Radiation on Dwarf Galaxy Formation around Milky Way Analogs across Cosmic Reionization

open access: yesThe Astrophysical Journal
We explore the effect of local stellar radiation on the formation and evolution of dwarf galaxies around Milky Way (MW) analogs. Using five simulations from the Auriga project, both with and without local stellar radiation, we find that local stellar ...
Bocheng Zhu, Liang Gao
doaj   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

Resolved Stellar Mass Estimation of Nearby Late-type Galaxies for the SPHEREx Era: Dependence on Stellar Population Synthesis Models

open access: yesThe Astronomical Journal
The upcoming all-sky infrared spectrophotometric SPHEREx mission is set to provide spatially resolved stellar mass maps of nearby galaxies, offering more detailed insights than integrated light observations.
Jeong Hwan Lee   +9 more
doaj   +1 more source

Galactic Stellar Populations

open access: yes, 2005
19 pages, invited review at the Cozumel/Cancun conference on Resolved Stellar Populations, April 2005. ASP Conference proceedings, eds D.
Wyse, Rosemary F. G., Gilmore, Gerard
openaire   +2 more sources

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

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