Results 211 to 220 of about 12,166 (296)

Sotatercept in Pulmonary Arterial Hypertension: Molecular Mechanisms, Clinical Evidence, and Emerging Role in Reverse Remodelling. [PDF]

Int J Mol Sci
Tilea I, Iancu DG, Fira-Mladinescu O, Bertici N, Varga A.   +4 more
europepmc   +1 more source

On Cepheid Distance Scale Bias Due to Stellar Companions and Cluster Populations [PDF]

, 2018
Richard I. Anderson, Adam G. Riess
openalex   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

A precise metallicity and carbon-to-oxygen ratio for a warm giant exoplanet from its panchromatic JWST emission spectrum. [PDF]

Proc Natl Acad Sci U S A
Wiser LS, Bell TJ, Line MR, Schlawin E, Beatty TG, Welbanks L, Greene TP, Parmentier V, Murphy MM, Fortney JJ, Arnold K, Mehta N, Ohno K, Mukherjee S.   +13 more
europepmc   +1 more source

DUSTiNGS. III. DISTRIBUTION OF INTERMEDIATE-AGE AND OLD STELLAR POPULATIONS IN DISKS AND OUTER EXTREMITIES OF DWARF GALAXIES

, 2020
Kristen B. W. McQuinn, Martha L. Boyer, Mallory B. Mitchell, Evan D. Skillman, Gehrz, M. A. T. Groenewegen, Iain McDonald, Sloan, J. Th. van Loon, P. A. Whitelock, A. A. Zijlstra   +10 more
openalex   +1 more source

Distinct core and halo stellar populations and the formation history of the bright Coma cluster early-type galaxy NGC 4889 [PDF]

, 2010
L. Coccato, Ortwin Gerhard, M. Arnaboldi
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The connection between the fastest astrophysical jets and the spin axis of their black hole. [PDF]

Nat Astron
Fender RP, Motta SE.
europepmc   +1 more source

Stellar Population Synthesis [PDF]

, 1997
openaire   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source