Results 211 to 220 of about 6,178,117 (397)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

JADES + JEMS: A Detailed Look at the Buildup of Central Stellar Cores and Suppression of Star Formation in Galaxies at Redshifts 3 < z < 4.5

The Astrophysical Journal
We present a spatially resolved study of stellar populations in six galaxies with stellar masses M _* ∼ 10 ^10 M _☉ at z ∼ 3.7 using 14-filter James Webb Space Telescope (JWST)/NIRCam imaging from the JADES and JEMS surveys. The six galaxies are visually
Zhiyuan Ji, Christina C. Williams, Sandro Tacchella, Katherine A. Suess, William M. Baker, Stacey Alberts, Andrew J. Bunker, Benjamin D. Johnson, Brant Robertson, Fengwu Sun, Daniel J. Eisenstein, Marcia Rieke, Michael V. Maseda, Kevin Hainline, Ryan Hausen, George Rieke, Christopher N. A. Willmer, Eiichi Egami, Irene Shivaei, Stefano Carniani, Stephane Charlot, Jacopo Chevallard, Emma Curtis-Lake, Tobias J. Looser, Roberto Maiolino, Chris Willott, Zuyi Chen, Jakob M. Helton, Jianwei Lyu, Erica Nelson, Rachana Bhatawdekar, Kristan Boyett, Lester Sandles   +32 more
doaj   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Age of Massive Galaxies at Redshift 8

The Astrophysical Journal
Recent James Webb Space Telescope data analyses have shown that massive red galaxies existed at redshifts z ≳ 6, a discovery that is difficult to understand in the context of standard cosmology (ΛCDM).
M. López-Corredoira, F. Melia, J.-J. Wei, C.-Y. Gao   +3 more
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Different Influence of Gas Accretion on the Evolution of Star-forming and Non-star-forming Galaxies

The Astrophysical Journal
Using integral field spectroscopic data from the Mapping Nearby Galaxies at Apache Point Observatory survey, we investigate the spatially resolved properties and empirical relations of a star-forming galaxy and a non-star-forming galaxy hosting ...
Min Bao, Wenlong Zhao, Qirong Yuan
doaj   +1 more source

Stellar-population samples at the galactic poles. I. Proper-motion stars, blue objects, and eclipsing binaries near the south pole

, 1968
O. J. Eggen
openalex   +1 more source

Stellar Populations at the Center of IC 1613 [PDF]

, 1999
Andrew A. Cole, Eline Tolstoy, J. S. Gallagher, J. G. Hoessel, J. R. Mould, Jon A. Holtzman, Abhijit Saha, G. E. Ballester, Christopher J. Burrows, J. T. Clarke, David Crisp, R. E. Griffiths, Carl J. Grillmair, J. J. Hester, John Krist, V. S. Meadows, Paul A. Scowen, Karl R. Stapelfeldt, John T. Trauger, A. M. Watson, J. Westphal   +20 more
openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

The Stellar Populations of Spiral Disks. II. Measuring and Modeling the Radial Distribution of Absorption Spectral Indices [PDF]

, 1999
M. Mollá, Eduardo Hardy, Dominique Beauchamp   +2 more
openalex   +1 more source