Results 221 to 230 of about 12,166 (296)

A Novel Hybrid High-Speed Mass Spectrometer Allows Rapid Translation From Biomarker Candidates to Targeted Clinical Tests Using ¹⁵N-Labeled Proteins. [PDF]

Mol Cell Proteomics
Wahle M, Remes PM, Albrecht V, Baggio Lorenz M, Mueller-Reif J, Steigerwald S, Heymann T, Niu L, Lössl P, Horning S, Jacob CC, Mann M.   +11 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Starspots as the origin of ultrafast drifting radio bursts from an active M dwarf. [PDF]

Sci Adv
Zhang J, Tian H, Bellotti S, Cang T, Callingham JR, Vedantham HK, Chen B, Yu S, Zarka P, Louis CK, Jiang P, Lu H, Gao Y, Sun J, Gan H, Li H, Sun C, Lei Z, Huang M.   +18 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

The Potential Impact of Sotatercept on Long-Term Disability in Commercially Insured Patients with Pulmonary Arterial Hypertension in the United States: An Exercise in Actuarial Modeling. [PDF]

Adv Ther
Watzker A, Alsumali A, Ferro C, Li XJ, Dieguez G, Park C, Chevure J, Lautsch D, El-Kersh K.   +8 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Background-free ¹²C(<i>α</i>, <i>γ</i>) angular distribution measurements with a time projection chamber operating in Gamma beams. [PDF]

Commun Phys
Haverson KCZ, Smith R, Gai M, Schweitzer DK, Stern SR, Finch SW.   +5 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Progenitor Systems of Classical Novae in M31. [PDF]

Astrophys J
Abelson CS, Badenes C, Chomiuk L, Williams BF, Breivik K, Galbany L, Jiménez-Palau C.   +6 more
europepmc   +1 more source

Looking into the faintEst WIth MUSE (LEWIS): on the nature of ultra-diffuse galaxies in the Hydra I cluster. V. Integrated stellar population properties

Doll, Goran, Buttitta, Chiara, Iodice, Enrichetta, Ferré-Mateu, Anna, Falcòn-Barroso, Jesus, Martìn-Navarro, Ignacio, Paolillo, Maurizio, Rossi, Luca, Forbes, Duncan A., Spiniello, Chiara, Hartke, Johanna, Gullieuszik, Marco, Arnaboldi, Magda, Cantiello, Michele, Corsini, Enrico Maria, D'Ago, Giuseppe, Hilker, Michael, La Marca, Antonio, Mieske, Steffen, Mirabile, Marco, Rejkuba, Marina, Spavone, Marilena   +21 more
openalex   +1 more source