Results 331 to 340 of about 6,178,117 (397)

CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu, Wentao Chen, Yahong Wu, Zhen Guo, Jun Chen, Chen Tian, Pan Wang, Shaopeng Zeng, Bin Xu, Jing Duan, Shilong Han, Xiao Xiong, Jing Zhang   +12 more
wiley   +1 more source

Population Pharmacokinetic/Pharmacodynamic and Exposure-Response Modeling Analyses of Sotatercept in Healthy Participants and Patients with Pulmonary Arterial Hypertension. [PDF]

Clin Pharmacol Ther
Ait-Oudhia S, Jaworowicz D, Hu Z, Gaurav M, Barcomb H, Hu S, Bihorel S, Balasubrahmanyam B, Mistry B, de Oliveira Pena J, Wenning L, Gheyas F.   +11 more
europepmc   +1 more source

Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden, Charles Carron, Donatienne Van Weehaeghe, Joke De Vocht, Fouke Ombelet, Pegah Masrori, Caro De Weerdt, Rebecca E. James, Lauren T. Evans, Frederick A. Schroeder, Jacob M. Hooker, Michel Koole, Janice E. Kranz, Tonya M. Gilbert, Philip Van Damme, Koen Van Laere   +15 more
wiley   +1 more source

Myostatin Levels in SMA Following Disease‐Modifying Treatments: A Multi‐Center Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study investigated myostatin levels in SMA patients receiving disease‐modifying therapies (DMTs) to understand their relationship with treatment duration and functional status. Methods Our study includes both cross‐sectional and longitudinal analyses of myostatin levels in treated SMA patients.
Fiorella Piemonte, Sara Petrillo, Anna Capasso, Giorgia Coratti, Adele D'Amico, Michela Catteruccia, Maria Carmela Pera, Concetta Palermo, Marika Pane, Emanuela Abiusi, Gianpaolo Cicala, Marianna Villa, Chiara Bravetti, Chiara Arpaia, Agnese Novelli, Salvatore Falqui, Stefania Fiori, Giulia Napoli, Silvia Baroni, Francesco Danilo Tiziano, Enrico Bertini, Giacomo Comi, Stefania Corti, Eugenio Mercuri   +23 more
wiley   +1 more source

A binary merger product as the direct progenitor of a Type II-P supernova

Niu* Z, Sun* N, Zapartas* E, Souropanis D, Cui Y, Maund JR, Andrews JJ, Briel MM, Fraser M, Gossage S, Kruckow MU, Liotine C, Liu Z, Srivas PM, Teng E, Wang X, Yang Y, Liu J.   +17 more
europepmc   +1 more source

One month convection timescale on the surface of a giant evolved star. [PDF]

Nature
Vlemmings W, Khouri T, Bojnordi Arbab B, De Beck E, Maercker M.   +4 more
europepmc   +1 more source

The Impact of Diabetes and Metabolic Syndrome Burden on Pain, Neuropathy Severity and Fiber Type

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Determine the association between diabetes and metabolic syndrome (MetS) burden (number of MetS criteria fulfilled) and pain, neuropathy severity, and fiber type involvement in individuals with established polyneuropathy. Methods The Peripheral Neuropathy Research Registry was queried for individuals with type 1 and type 2 diabetes ...
Long Davalos, Brian C. Callaghan, Lavanya Muthukumar, Simone Thomas, Evan L. Reynolds, A. Gordon Smith, J. Robinson Singleton, Ahmet Höke, Senda Ajroud‐Driss, Mazen M. Dimachkie, Stefanie Geisler, David M. Simpson, PNRR Study Group, Amro M. Stino   +13 more
wiley   +1 more source

Witnessing the onset of reionization through Lyman-α emission at redshift 13. [PDF]

Nature
Witstok J, Jakobsen P, Maiolino R, Helton JM, Johnson BD, Robertson BE, Tacchella S, Cameron AJ, Smit R, Bunker AJ, Saxena A, Sun F, Alberts S, Arribas S, Baker WM, Bhatawdekar R, Boyett K, Cargile PA, Carniani S, Charlot S, Chevallard J, Curti M, Curtis-Lake E, D'Eugenio F, Eisenstein DJ, Hainline KN, Jones GC, Kumari N, Maseda MV, Pérez-González PG, Rinaldi P, Scholtz J, Übler H, Williams CC, Willmer CNA, Willott C, Zhu Y.   +36 more
europepmc   +1 more source