Results 71 to 80 of about 165,855 (235)

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Metal-poor Stars in the MW Disk: Resonant Cooling of Vertical Oscillations of Halo Stars in Barred Galaxies

The Astrophysical Journal Letters
Using numerical simulations of a barred disk galaxy embedded in nonspinning and spinning dark matter (DM) halos, we present a novel mechanism of “cooling” the vertical oscillations of DM particles, which acquire disk kinematics.
Xingchen Li, Isaac Shlosman, Daniel Pfenniger, Clayton Heller   +3 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Stellar Ages: A Code to Infer Properties of Stellar Populations

The Astrophysical Journal
We present a novel statistical algorithm, Stellar Ages, which currently infers the age, metallicity, and extinction posterior distributions of stellar populations from their magnitudes.
Joseph J. Guzman, Jeremiah W. Murphy, Andrés F. Barrientos, Benjamin F. Williams, Julianne J. Dalcanton   +4 more
doaj   +1 more source

Structure of the SMC - Stellar component distribution from 2MASS data

, 2008
The spatial distribution of the SMC stellar component is investigated from 2MASS data. The morphology of the different age populations is presented. The center of the distribution is calculated and compared with previous estimations.
A. Karampelas, Begum, Cioni, Cote, E. Kontizas, E. Livanou, Freeman, Gardiner, Haynes, I. Gonidakis, M. Belcheva, M. Kontizas, Maragoudaki, Morgan, P. Tsalmantza, Stanimirovic, Strigari, U. Klein   +17 more
core   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

The MASSIVE Survey II: Stellar Population Trends Out to Large Radius in Massive Early Type Galaxies

, 2015
We examine stellar population gradients in ~100 massive early type galaxies spanning 180 < sigma* < 370 km/s and M_K of -22.5 to -26.5 mag, observed as part of the MASSIVE survey (Ma et al. 2014).
Blakeslee, John P., Greene, Jenny E., Janish, Ryan, Ma, Chung-Pei, McConnell, Nicholas J., Murphy, Jeremy D., Thomas, Jens   +6 more
core   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Stellar Population Diagnostics of Elliptical Galaxy Formation

, 2006
Major progress has been achieved in recent years in mapping the properties of passively-evolving, early-type galaxies (ETG) from the local universe all the way to redshift ~2.
Alvio Renzini, Arimoto N, Bower G, Bower G, Bressan A., Busarello G, Ciotti L, da Costa LN, Daddi E, Daddi E, Faber SM, Fioc M, Franx M, Gavazzi G, Gorgas J, Hogg D, Jørgensen I, Kodama T, Kodama T, Kormendy J, Lilly SJ, Norman CA, Prugniel Ph, Renzini A, Tantalo R, Tinsley BM, Vazdekis A, Vázques GA, Weiss A, Worthey G, Ziegler BL   +30 more
core   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source