Results 261 to 270 of about 108,892 (343)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Postmarketing analysis of sotatercept: identifying serious unlabelled events. [PDF]

Open Heart
Cao Z, Xiao Q, Li X, Zhang H, Zhang M.
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Tumor Treating Fields (TTFields) Therapy in Unresectable Pleural Mesothelioma: Overview of Efficacy, Safety, and Future Outlook. [PDF]

Curr Treat Options Oncol
Ceresoli GL, Gianoncelli L.
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Utilization of youth corners: a model for improving youth-friendly health services in Neno District, Southern Malawi. [PDF]

Glob Health Action
Kavuma T, Chibvunde S, Kabanda V, Munyaneza F, Mpinga K, Mphande I, Nhlema B, Banda C, Harare J, Ndarama E, Sandiyang'ane A, Aron MB.   +11 more
europepmc   +1 more source

Understanding sub-stellar populations using wide-field infrared surveys

, 2011
D. J. Pinfield, A. C. Day-Jones, Ben Burningham, S. K. Leggett, H. Beaumont, Motohide Tamura, C. G. Tinney, Meijun Liu, D. Homeier, N. Lodieu, N. R. Deacon, Andrew A. West, N. Huélamo, Trent J. Dupuy, D. Mortlock, S. J. Warren, H. R. A. Jones, P. W. Lucas, M. Ishi, R. G. McMahon, P. C. Hewett, M. R. Zapatero Osorio, E. L. Martín, Bram Venemans, D. Barrado, Z. Zhang, M. Morales‐Calderón   +26 more
openalex   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Planets larger than Neptune have elevated eccentricities. [PDF]

Proc Natl Acad Sci U S A
Gilbert GJ, Petigura EA, Entrican PM.
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source