Results 101 to 110 of about 152,062 (293)
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
The ACRIM data in the context of stellar variability [PDF]
The Active Cavity Radiometer Irradiance Monitor (ACRIM) total-irradiance data from the Solar Maximum Mission have given a first comprehensive view of solar variability in the stellar sense.
Hudson, Hugh S.
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Stellar Models Also Limit Exoplanet Atmosphere Studies in Emission
Stellar contamination has long been recognized as a major bottleneck in transmission spectroscopy, limiting our ability to accurately characterize exoplanet atmospheres—particularly for terrestrial worlds.
Thomas J. Fauchez +5 more
doaj +1 more source
Absolute Lineshifts - A new diagnostic for stellar hydrodynamics [PDF]
For hydrodynamic model atmospheres, absolute lineshifts are becoming an observable diagnostic tool beyond the classical ones of line-strength, -width, -shape, and -asymmetry.
Dravins, Dainis
core +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
There is now a large sample of stars observed by the Kepler satellite with measured rotation periods and photometric activity index S _ph . We use this data, in conjunction with stellar interiors models, to explore the interplay of magnetism, rotation ...
Savita Mathur +18 more
doaj +1 more source
A “Wonderful” Reference Dataset of Mira Variables
The conditions in Mira variable atmospheres make them wonderful laboratories to study a variety of stellar physics such as molecule–grain formation, dust production, shock chemistry, stellar winds, mass loss, opacity-driven pulsation, and shocks. We were
Dana K. Baylis-Aguirre +2 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source

