Results 121 to 130 of about 152,062 (293)

Seeking Spectroscopic Binaries with Data-driven Models

The Astrophysical Journal
Data-driven stellar classification has a long and important history in astronomy, dating as far back as Annie Jump Cannon’s “by-eye” classifications of stars into spectral types, still used today.
Isabel Angelo, Erik Petigura, Megan Bedell   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Differential Rotation of CoRoT Stars and a Kepler Binary Star from Starspot Transit Mapping

The Astrophysical Journal
While direct magnetic field measurements are rare for slowly rotating stars, spots observed during planetary transits provide a potential indicator of magnetic activity on stellar surfaces.
Adriana Valio, Alexandre Araújo, Fabian Menezes   +2 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Disks around O-type young stellar objects

, 2020
Accretion disks are one of the key ingredients of the star formation process. They redistribute angular momentum and, in the case of high-mass stars (M > 8Msun), disks would relieve the radiation pressure on the accreting material, in particular in the equatorial direction, by beaming the radiation through the poles of the system and this would allow ...
openaire   +4 more sources

Evolution of Stellar Activity and Habitable Zone. II. Ca II H and K Emissions of Late-type Dwarfs

The Astrophysical Journal Supplement Series
Stellar chromospheric activity serves as a valuable proxy for estimating stellar ages, though its applicable range and accurate functional form are still debated.
Henggeng Han, Song Wang, Xue Li, Chuanjie Zheng, Jiahui Wang, Jifeng Liu   +5 more
doaj   +1 more source

Stellar population gradients in early-type galaxies

The Astrophysical Journal, 1992
Long-slit spectroscopy, covering the wavelength range 3600-4600 A at 5.3 A FWHM resolution, has been obtained for a sample of seven elliptical and S0 galaxies. The two-dimensional spectra have been spatially binned to provide good signal-to-noise ratio (S/N∼40 per 5.3 A spectral resolution element), spatially resolved spectra out to 0.5-1 half-light ...
openaire   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source