Results 131 to 140 of about 152,062 (293)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

SpecCLIP: Aligning and Translating Spectroscopic Measurements for Stars

The Astrophysical Journal
In recent years, large language models (LLMs) have transformed natural language understanding through vast data sets and large-scale parameterization. Inspired by this success, we present SpecCLIP, a foundation model framework that extends LLM-inspired ...
Xiaosheng Zhao, Yang Huang, Guirong Xue, Xiao Kong, Jifeng Liu, Xiaoyu Tang, Timothy C. Beers, Yuan-Sen Ting, A-Li Luo   +8 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Evolution of Stellar Activity and Habitable Zone. I. Ultraviolet Emission of Dwarfs in Open Clusters and Field Stars

The Astrophysical Journal Supplement Series
Near-ultraviolet (NUV) radiation from dwarf stars plays a critical role in shaping the habitability of planetary systems, yet its long-term evolution across different spectral types remains poorly investigated.
Xue Li, Song Wang, Jun Ma, Henggeng Han, Yang Huang, Jifeng Liu   +5 more
doaj   +1 more source

Revisiting the exoplanet radius valley with host stars from SWEET-Cat

Astronomy & Astrophysics
Context. The radius valley, a deficit in the number of planets with radii around 2 R⊕, was observed among exoplanets that have sizes of ≲5 R and orbital periods of
Kamulali J., Adibekyan V., Nsamba B., Sousa S. G., Campante T. L., Weiss A., Kabugho B., Moedas N., Santos N. C., Trust O.   +9 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

First JWST/NIRSpec Spectroscopy of O Stars in the Small Magellanic Cloud

The Astrophysical Journal Letters
Determining how much mass is removed by stellar winds is crucial to understanding massive star evolution and feedback. However, traditional spectroscopic diagnostics in the UV and optical are not sensitive enough to characterize weak stellar winds of OB ...
Armin Mang Román, Peter Zeidler, Wolf-Rainer Hamann, Lidia M. Oskinova, M. J. Rickard, S. Reyero Serantes, H. Todt, J. S. Gallagher III, D. Massa, D. Pauli, V. Ramachandran, E. Sabbi, A. A. C. Sander   +12 more
doaj   +1 more source