Results 141 to 150 of about 152,062 (293)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A Spectroscopic Survey of Metal-poor OB Stars in Local Dwarf Galaxy NGC 3109

The Astrophysical Journal
As JWST uncovers increasingly strong evidence that metal-poor, massive stars in early galaxies dominated reionization, observational constraints on the properties of such stars are more relevant than ever before.
Abby Mintz, O. Grace Telford, Evan N. Kirby, John Chisholm, Kristen B. W. McQuinn, Danielle A. Berg   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Single-star Warm-Jupiter Systems Tend to Be Aligned, Even around Hot Stellar Hosts: No T eff–λ Dependency

The Astrophysical Journal Letters
The stellar obliquity distribution of warm-Jupiter systems is crucial for constraining the dynamical history of Jovian exoplanets, as the warm Jupiters’ tidal detachment likely preserves their primordial obliquity.
Xian-Yu Wang, Malena Rice, Songhu Wang, Shubham Kanodia, Fei Dai, Sarah E. Logsdon, Heidi Schweiker, Johanna K. Teske, R. Paul Butler, Jeffrey D. Crane, Stephen Shectman, Samuel N. Quinn, Veselin Kostov, Hugh P. Osborn, Robert F. Goeke, Jason D. Eastman, Avi Shporer, David Rapetti, Karen A. Collins, Cristilyn N. Watkins, Howard M. Relles, George R. Ricker, Sara Seager, Joshua N. Winn, Jon M. Jenkins   +24 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Metal Pipe: A Broadly Applicable Stellar Abundance Pipeline Using Isochronal Parameters

The Astrophysical Journal
Characterizing exoplanet host stars at the population level requires a method of homogeneously characterizing stellar properties across all spectral types.
Jared R. Kolecki, Lauren M. Weiss
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

A Chemically Peculiar Star Catalog from LAMOST DR12 Based on Deep Learning

The Astrophysical Journal Supplement Series
Chemically peculiar (CP) stars offer a unique observational sample for exploring key processes in stellar evolution. Leveraging the massive amounts of data obtained from large-scale sky surveys, deep learning technology has significantly advanced ...
Yixing Chen, Hui Deng, Lei Tan, Ying Mei, Feng Wang   +4 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source